Psychiatr. praxi. 2016;17(1):6-8 | DOI: 10.36290/psy.2016.002

Trazodone in the treatment of behavioral and psychological symptoms of dementia

doc. MUDr. Roman Jirák, CSc.
Psychiatrická klinika 1. LF UK v Praze

The effect of trazodone on behavioral and psychological symptoms of dementia was examined in a postauthorisation noninterventional study in patients suffering from different types of demenia. Trazodone controlled-release (Trittico AC) proved to be an effective treatment with minimal side effects. Sleep disorders, depression, anxiety and agitation were affected to the highest degree. Trazodone represents a more safe alternative to the commonly used antipsychotic drugs.

Keywords: behavioral and psychological symptoms of dementia, postauthorisation study, dementia, depression, trazodone

Published: March 1, 2016  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Jirák R. Trazodone in the treatment of behavioral and psychological symptoms of dementia. Psychiatr. praxi. 2016;17(1):6-8. doi: 10.36290/psy.2016.002.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Henry G, Williamson D, Tampi RR. Efficacy and Tolerability of Antidepressants in the Treatment of Behavioral and Psychological Symptoms of Dementia. A Literature Review of Evidence. Am J Alzheimers Dis Other Demen. 2011; 26(3): 169-183. Go to original source...
    2. Hershey LA, Aggarwal R, Jindal P, Baranskaya I. Managing Agitation in Alzheimer Disease and Related Disorders. JSM Alzheimer's Dis Related Dementia 1(2): 1007.
    3. Kaye ED, Petrovic-Poljak A, Verhoeff NPLG, Freedman M. Frontotemporal Dementia and Pharmacologic Interventions. The Journal of Neuropsychiatry and Clinical Neurosciences 2010; 22: 19-29. Go to original source...
    4. Raboch J. Zařazení antidepresiva trazodonu v klinické praxi. Practicus, 2009; 8(2): 24-26.
    5. Camargos EF, Pandolfi MB, Freitas MPD, Quintas JL, Lima J. De Oliviera, Miranda LC, Pimentel LW, Medeiros-Souza P. Trazodone for the Treatment of Sleep Disorders in Dementia. Arq Neuropsiquiatr 2011; 69(1): 44-49. Go to original source... Go to PubMed...
    6. Češková E. Trazodon v neurologické praxi. Neurológia pre prax 2006; 7(2): 120-122.
    7. Jirák R. Použití trazodonu k léčbě behaviorálních a psychologických příznaků demence. Česká a slovenská psychiatrie, 2013; 109(5): 224-226.
    8. Lebert F, Stekke W, Hasenbroekx Ch, et al. Frontotemporal Dementia: A Randomised, Controlled Trial with Trazodone. Dementia and Geriatric Cognitive Diasorders, 2004; 17(4): 355-359. Go to original source... Go to PubMed...
    9. Lužný J. Naše zkušenosti s léčbou behaviorálních a psychologických příznaků trazodonem u pacientek s mírnou nebo středně těžkou Alzheimerovou chorobou. Psychiatrie pro praxi, 2014; 15(3): 118-121.
    10. Martinón-Torres G, Fioravanti M. Trazodone for agitation in dementia. The Cochrane Library, Cochrane Dementia and Cognitive Improvement Group. Published online 16 JUL 2008. DOI: 10.1002/14651858.CD004990. Go to original source...
    11. Šulcová A. Multimodální farmakologické působení tarzodonu. Psychiatrie 2015; 19(1): 49-52.
    12. Cummings JL. The Neuropsychiatric Inventory: Assessing psychopathology in dementia patients. Neurology 1997; 48 (Suppl. 6): S10-S16. Go to original source...
    13. Teng E, et al. Diagnosing Depression in Alzheimer Disease With the National Institute of Mental Health Provisional Criteria. Am J Geriatr Psychiatry. 2008; 16(6): 469-477. Go to original source...

    Return to the content


    Psychiatry for Practice

    Madam, Sir,
    please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
    Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

    I declare:

    1. that I have met the above instruction
    2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited

    No
    Yes

    If your statement is not true, please be aware
    that brings the risk of danger to their health or the health of others.