Psychiatr. praxi. 2021;22(3):138-142 | DOI: 10.36290/psy.2021.030

Treatment options for pharmacoresistant depression in routine clinical practice

prof. MUDr. Eva Češková, CSc.^{1, 2, 3}

¹ Psychiatrická klinika LF MU a FN Brno

² KNP LF Ostravské univerzity

³ Oddělení psychiatrické FN Ostrava

Patients with first-episode patients differ from those with multi-episode and chronic schizophrenia in several important aspects. While treatment response the first-episode is better, the risk of relapse is higher. Poor medication adherence is a significant problem in early psychosis Both first- and second-generation antipsychotics are very effective in reducing symptoms, however, there are tolerability and retention in treatment advantages for the second-generation antipsychotics in first-episode psychosis. The early years after the first-episode a represent a critical period for further outcome and the best opportunity for achieving optimal outcomes.

Keywords: first‑episode schizophrenia, treatment response, retention in treatment, adherence, critical period.

Published: October 14, 2021  Show citation