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MUDr. Radkin Honzák, CSc.

Psychiatr. praxi. 2025;26(2):67

Pharmacokinetic aspects of the treatment with long-acting injectable antipsychotics and specific features of the first generation preparations

MUDr. Martin Hýža, Ph.D., MUDr. Tomáš Skřont

Psychiatr. praxi. 2025;26(2):71-74 | DOI: 10.36290/psy.2025.013

Long acting injectable antipsychotics overcome few troubles related to long term treatment of patients with schizophrenia, especially the frequent non-adherence. They are used in the treatment of schizophrenia for almost 60 years. Compared to per os drug forms, the principles of pharmacokinetics are different. Its dynamics is led by the amount of a drug released from the site of application. Using the simple conversion of equivalent dose is burdened with a risk of plasma level decline and resulting increased risk of relapse; to overcome this, using of per os supplementation or loading patterns is recommended. The use of TDM is advantageous during switch...

Generalized anxiety disorder and its treatment

MUDr. Katarína Adamcová, MUDr. Pavla Stopková, Ph.D., Mgr. Markéta Jablonská, Mgr. David Jakeš, Barbora Darmová, Mgr. et Mgr. Iveta Fajnerová, Ph.D.

Psychiatr. praxi. 2025;26(2):75-82 | DOI: 10.36290/psy.2025.014

Generalized Anxiety Disorder (GAD) is characterized by chronic and excessive worries across various aspects of daily life, including personal and work-related responsibilities, health, and interpersonal relationships. The diagnostic criteria undergo a slight modification with the transition from the 10th edition of the International classification of diseases (ICD-10) to the new version, ICD-11. This article examines the changes in the new classification, which is expected to become the diagnostic guideline in the coming years. The aim of this article is to explore in detail the characteristics of generalized anxiety disorder, its diagnostic challenges,...

Treatment of pharmacoresistant states in psychiatry. Part 2: Treatment-resistant depression

prof. MUDr. Eva Češková, CSc.

Psychiatr. praxi. 2025;26(2):83-86 | DOI: 10.36290/psy.2025.015

The paper is focused on pharmacotherapy of treatment-resistant depression and presents the treatment possibilities, e.g. switch to another antidepressant, augmentation and combination of antidepressants. In more details the augmentation with the first (ketamine, esketamine) and the second generation (esmethadone) of uncompetitive NMDA receptors antagonists, so called rapid acting antidepressants is described. Further, there are mentioned some substances used before psychopharmacological era (opioids, psilocybin) and alternative approaches (nutraceuticals, probiotics), which have certain potential to reduce severe depressive symptoms.

The effect of transcranial magnetic stimulation on cognitive functions in patients with depression

Mgr. Markéta Kubinová, doc. MUDr. Lucie Kališová, Ph.D.

Psychiatr. praxi. 2025;26(2):88-92 | DOI: 10.36290/psy.2025.016

Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive biological treatment method in many psychiatric, neurological, and otolaryngological indications. In psychiatry, rTMS proved its treatment effect mainly in the treatment of depression. rTMS is a well-tolerated treatment method, and side effects occur with proper indication and preparation rarely. This review brings comprehensive information about the impact of rTMS on cognitive performance in patients with depression. Results conclude that rTMS does not impair cognitive functions and, on the other hand, has a potential for improvement of cognition. This article confirms the safety...

The phenomenon of nonsuicidal self-injury - how can we help effectively? Part 1: Understanding nonsuicidal self-injury as a symptom

MUDr. Michaela Chmelíková

Psychiatr. praxi. 2025;26(2):94-100 | DOI: 10.36290/psy.2025.017

This article first explores the theoretical framework of nonsuicidal self-injury (NSSI) (definition, classification, epidemiology, etiological factors) and then presents current findings on the behavioral manifestations of self-injurious behavior. Special emphasis is placed on conveying an understanding of the subjective experiences and needs of individuals suffering from this symptom. Understanding is shown to be a crucial factor in shaping an appropriate professional approach to the issue. The topic of NSSI is burdened by numerous myths and stigmatizing prejudices, which can either directly discourage affected individuals from seeking professional...

Internet psychoeducation and psychotherapy for obsessive-compulsive disorder - review

MUDr. Jan Pásztor, prof. MUDr. Ján Praško, Ph.D., MUDr. Jakub Vaněk, Ph.D., MUDr. Jozef Višňovský, doc. PhDr. PaedDr. Marta Zaťková, PhD., PhDr. Miloš Šlepecký, CSc., prof. PhDr. Tomáš Sollár, PhD., MUDr. Vlastimil Nesnídal

Psychiatr. praxi. 2025;26(2):101-106 | DOI: 10.36290/psy.2025.018

Objective: The aim of this review article is to describe the effectiveness and accessibility of internet-based psychoeducation and psychotherapy for obsessive-compulsive disorder (OCD). The focus is on various forms of internet therapy, including cognitive behavioral therapy (CBT), acceptance and commitment therapy (ACT), and mindfulness techniques. Methods: Relevant studies published between 2010 and 2024 were selected for this review. Randomized controlled trials, meta-analyses, and systematic reviews evaluating the effectiveness of internet-based psychoeducation and psychotherapy for patients with OCD were included. Data were analyzed for effectiveness,...

The diagnosis and pharmacotherapy of Adult ADHD - part 1

MUDr. Michal Vodička

Psychiatr. praxi. 2025;26(2):108-115 | DOI: 10.36290/psy.2025.019

The introductory part of this review article on ADHD presents the prevalence, historical development, etiology, symptoms and diagnosis, including the importance of psychological assessment. It also discusses the pharmacotherapeutic options available in the Czech Republic, including their efficacy, side effects, interactions with other medications, potential health risks, and specific aspects of use in pregnancy and lactation. It also describes the differences between ADHD in childhood and adulthood.

Altered pharmacokinetics of selected psychopharmaceuticals in patients with chronic kidney disease

Mgr. Michaela Jelínková, PharmDr. Jan Miroslav Hartinger, Ph.D.

Psychiatr. praxi. 2025;26(2):116-122 | DOI: 10.36290/psy.2025.020

Psychiatric illness and delirious states treated with psychopharmaceuticals are common comorbidities in patients with renal impairment. Although the conventional wisdom is that most psychopharmaceuticals are lipophilic in nature and are not renally eliminated, this is not true for a number of commonly administered drugs, and their dosing needs to be adjusted in patients with chronic kidney disease (CKD) or acute kidney injury (AKI). The present article focuses on the effect of impaired renal function and extracorporeal elimination methods on renally eliminated psychopharmaceuticals, especially thiapride, amisulpride, sulpiride, risperidone, paliperidone,...

Comorbid anorexia nervosa and obsessive-compulsive disorder in adolescence - a case report

MUDr. Barbora Pilátová, MUDr. Kryštof Kantor, Ph.D., doc. PhDr. Jana Kocourková

Psychiatr. praxi. 2025;26(2):123-126 | DOI: 10.36290/psy.2025.021

Anorexia nervosa and obsessive-compulsive disorder (OCD) are mental disorders that often develop during adolescence. These conditions share some common features and can occur simultaneously, which can lead to complications in the diagnosis and treatment of both disorders. Adolescence is a specific period of life that is associated with rapid changes in psychological status, even in the absence of pathology. In the case study of an adolescent girl, we highlight the phenomenological overlap in symptomatology between these two comorbid disorders and the fact that correct differentiation of the causes of the observed behaviours can play an important role...

Léčba hypomagnezemie jako možné příčiny některých symptomů neurologických poruch

MUDr. Jiří Havel, MSc.

Psychiatr. praxi. 2025;26(2):130-134

Highligths: informace a dojmy z 10. mezinárodního sympozia Světové federace ADHD

MUDr. Hedvika Ernsten

Psychiatr. praxi. 2025;26(2):127-129