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Metabolic syndrome (MS) is a complex of metabolic changes that includes abdominal obesity, elevation of blood pressure, impairment of glucose tolerance and lipid changes. The prevalence of MS is higher in patients with schizophrenia than in general population. Its presence may affect the elevated mortality rate among the patients. The interest in the influence of pharmacological treatment on the incidence of metabolic syndrome in patients with schizophrenia appeared after the second generation of antipsychotic drugs had been introduced. The results of studies that investigated the association of the metabolic syndrome with pharmacological treatment...
Psychiatr. pro Praxi, 2006; 5: 211-213 
Osteoporosis is a multifactorial disease. Untreated patients with schizophrenia are at risk due to the consequences of the disease related lifestyle factors (nutritional alteration, smoking, polydipsia, lack of physical activity). The etiology of the osteoporosis may be partly explained by the prolacting-raising effect of antipsychotic medication. Hyperprolactinemia itself does not lead to osteoporosis. Decrease of bone mineral density associated with schizophrenia may result from hypogonadism secondary to antipsychotic-induced hyperprolactinemia. The most common clinical signs of hypogonadism is dys/amenorrhea, and galactorrhea in female patients,...
Psychiatr. pro Praxi, 2006; 5: 214-224 
The introduction of antidepressants revolutionized not only the treatment of depression but also the way we view the disease itself. In this article, we discuss the treatment of depression, with a focus on proper evaluation, choice of an agent and strategies in the case of resistance to the treatment.
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Lamotrigine is an anticonvulsant drug with good efficacy and safety in the treatment of epilepsy. There is now substantial evidence that lamotrigine is also useful in treating bipolar disorder, resistant depression, rapid cycling bipolar disorder and in the maintenance phase or profylaxis of bipolar disorder. Recent reports suggesting that lamotrigine can be also an effective possibility for treatment in borderline personality disorder, a common comorbid personality disorder in bipolar patients, have possible role in reducing chronic pain and treating schizoaffective disorder.
Psychiatr. pro Praxi, 2006; 5: 225-228 