Psychiatr. pro Praxi, 2001; 1: 18-19

Syndrom z vysazení SSRI

MUDr. Slavomír Spousta
Psychiatrické oddělení Nemocnice v Českých Budějovicích

Keywords: antidepressants, SSRI, syndrome of withdrawal.

Published: December 31, 2001  Show citation

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Spousta S. Syndrom z vysazení SSRI. Psychiatr. praxi. 2001;2(1):18-19.

Při terapii antidepresiv ze skupiny selektivních inhibitorů zpětného vstříkávání serotoninu (SSRI) může docházet ke vzniku syndromu z vysazení. Přestože jde o relativně málo závažnou komplikaci léčby, může způsobit výraznou subjektivní nepohodu pacienta. Nerozpoznání souvislosti obtíží se syndromem z vysazení může pak lékaře vést k nesprávnému vedení terapie. Článek uvádí klinické situace, při nichž se může syndrom z odnětí objevit, jeho klinické příznaky, některé hypotézy o biologickém mechanismu vzniku příznaků a postupy při předcházení vzniku syndromu z vysazení a zvládání příznaků.

Syndrome because of SSRI discontinuing

Syndrome of withdrawal can accompany therapy by antidepressants from group of SSRI. Although this is considered to be relatively less serious complication of therapy, it can generate severe discomfort for a patient. If withdrawal syndrome is not recognized it could lead to incorrect direction of therapy by a physician. The article defines clinical situations, when withdrawal syndrome can occur, its clinical hall marks, some hypotheses on biological mechanism of symptoms origin and approaches in preventing withdrawal syndrome and management of its symptoms.

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References

  1. Lejoyeux M., Adés J.: Antidepressant Discontinuation: A Rewiew of the Literature. J Clin Psychiatry 1997, 58 (Supl 7).
  2. Black K., Shea C., Dursun S., Kutcher S.: Selective serotonin reuptake inhibitor discontinuation syndrome: proposed diagnostic criteria. J Psychiatry Neurosci 2000, 25 (3): 255-61.
  3. Zajecka J., Tracy K.A., Mitchell S.: Discontinuation Symptoms After Treatment With Serotonin Reuptake Inhibitors: A Literature Review. J Clin Psychiatry 58, July 1997. Go to original source... Go to PubMed...
  4. Schatzberg A.F., Haddad P., Kaplan E.M., Leyoux M., Rosenbaum J.F., Young A.H., Zajecka J.: Possible Biological Mechanisms of the Serotonin Reuptake Inhibitor Discontinuation Syndrome. J Clin Psychiatry 1997, 58 (suppl 7).
  5. Schatzberg A.F., Haddad P., Kaplan E.M., Leyoux M.,Rosenbaum J.F., Young A.H., Zajecka J.: Serotonin Reuptake Inhibitor Discontinuation Syndrome: A Hypothetical Definition. J Clin Psychiatry 1997, 58 (suppl 7).
  6. Švestka J.: SSRI - léky prvé volby, MAXDORF, 1998.




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