Psychiatr. pro Praxi, 2001; 1: 20-24
Nově registrovaná antipsychotika
- MUDr. Dagmar Seifertová CSc
- Psychiatrické centrum Praha, 3. LF UK, Praha
Keywords: atypical neuroleptics, quetiapine, amisulprid, ziprasidon, zotepine.
Published: December 31, 2001 Show citation
Seifertová D. Nově registrovaná antipsychotika. Psychiatr. praxi. 2001;2(1):20-24.
V posledních dvou letech byla registrována v ČR celkem 4 atypická neuroleptika: quetiapin, amisulprid, ziprasidon a zotepin. Ve stručném přehledu je shrnut jejich farmakologický profil, farmakodynamické a farmakokinetické vlastnosti, klinické studie a nežádoucí účinky. Tato neuroleptika znamenají rozšíření spektra nám dostupných léků a až klinická praxe prokáže jejich výhodnost nebo naopak nevýhodnost pro naše pacienty.
New registrated antipsychotics
During last 2 years 4 atypical neuroleptics have been registered: quetiapine, amisulprid, ziprasidon, zotepine. In a brief review their pharmacological profile, pharmacodynamic and pharmacokinetic properties, clinical studies and side effects are given. These neuroleptics render us more choices of available drugs, but only clinical practice will prove their advantage or disadvantage for our patients.
Download citation
References
- Švestka J : Nová psychofarmaka : antipsychotikum quetiapin. Psychiatrie 2000, 2: 120-33.
- Borison et al: Efficacy and safety in a multicenter, placebo-controlled trial in patients with schizophrenia. J Clin Psychopharmacol 1996, 16: 158-169.
Go to original source...
Go to PubMed...
- Small JG, Hirsch SR, Arvanitis LA, Miller BG, Link CGG and Seroquel study group. Quetiapine in patients with schizophrenia. A high and low-dose doubleblind comparison with placebo. Arch Gen Psychiat 1997, 54: 549-557.
Go to original source...
Go to PubMed...
- Peuskens J, Link CGG. A comparison of quetiapin and chlorpromazine in the treatment of schizophrenia. Acta Psychiat Scand 1197, 96: 265-273.
Go to original source...
- Arvanitis LA, Miller BG, Seroquel Trial 13 Study Group. Multiple fixed doses of Seroquel in patients with acute exacerbation of schizophrenia: A comparison with haloperidol and placebo. Biol Psychiat 1997,42: 233-246.
Go to original source...
Go to PubMed...
- Murasaki et al.Clinical evaluation of quetiapin in schizophrenia - efficacy and tolerability of quetiapine copared with haloperidol in patients with schizophrenia. World Congress of Psychiatry, Hamburg, Abstracts 1999, 279.
- Copolov DL, Link CGG, Kowalcyk B. Multicenter, double-blind, randomized comparison of quetiapine and haloperidol in schizophrenia. Psychol Med 2000, 30: 95-106.
Go to original source...
Go to PubMed...
- Veligan DI, Newcomer J, Pultz J, Csernansky J, Hoff AL, Mahurin R, Miller A. Changes in cognitive functioning with quetiapine fumarate versus haloperidol. APA Annual Meeting, Washington, Abstracts (NR)1999, 247.
- Purdon S, Malla A, Lebelle A, Litt W. Long-term treatment with quetiapine improves cognitive function in schizophrenia: A double-blind study. ACNP Annual Meeting, Acapulco, Abstracts 1999, 147.
- Meats P. Quetiapine: An effective and well-tolerated atypical antipsychotic. Int J Psychiat Clin Pract 1997, 1: 231-239.
Go to original source...
Go to PubMed...
- Tariot P, Slazman C, Yeung P, Pultz J, Goldstein J. Clinical improvement and tolerability is maintained long-term in elderly patients with psychotic disorders treated with quetiapin. Eur Neuropsychopharmacol 1999 (Suppl. 5): 268.
Go to original source...
- Goldstein JM. Quetiapine fumarate: A new atypical antipsychotic. Drugs Today 1999: 35: 193-210.
Go to original source...
Go to PubMed...
- Švestka J.: Amisulprid - atypický preparát ve skupine antipsychotik 2. Generace. Psychiatrie 2000, 3: 191-200.
- Pichot P, Boeyer P. Etude multicentrique controlee en double insu. Amisulpride verusu haloperidol a forte dose dans les états psychotiques aigues. Ann Psychiat 1988, 3: 326-332.
- DelckerA, Schoon ML, Pczkowski B, Gaertner HJ. Amisulpride versus haloperidol in treatment of schizophrenic patients - results of a double-blind study. Pharmacopsychiatry 1990, 23: 125-130.
Go to original source...
Go to PubMed...
- Boyer P, Turjanski S, Fleurot O. Amisulpride in the treatment of acute schizophrenie: A double-blind comparison with haloperidol. Eur Neuropsychopharmacol 1996, 6 (Suppl. 3) 60.
Go to original source...
- Moeller HJ, Boyer P, Fleurot O, Rein W. Improvement of acute exacerbation of schizophrenia with amisulpride. A comparison with haloperidol. Psychopharmacology 1997, 132: 396-401.
Go to original source...
Go to PubMed...
- Wetzel H, Gruender G, Hillert A, Philipp M, Gattaz WF et al. Amisulpride versus flupentixol in acute schizophrenia. Psychopharmacology 1998, 137: 223-232.
Go to original source...
Go to PubMed...
- Puech A, Fleurot o, Rein W. Amisulpride in the treatment of acute episodes of schizophrenia. A dose ranging study vs haloperidol. Acta Psychiat Scand 1998, 98: 65-72.
Go to original source...
Go to PubMed...
- Peuskens J, Bech P, Moeller HJ, Bale R, Rein W. Amisulpride v. risperidone in the treatment of acute exacerbation of schizophrenia. Psychiatry Res 1999, 88: 107-117.
Go to original source...
Go to PubMed...
- Lemperiére T et al. Efficacy and safety of amisulpride v. haloperidol. Eur Neuropsychopharmacology 1999, 9 (Suppl.5): 278.
Go to original source...
- SaletuB, Kufferle B, Grundberger J, Foldes P. Clinical, EEG maping and psychometric studies in negative schizophrenia. Comparative trial with amisulpride and flufenazine. Neuropsychobiology 1994, 29: 125-135.
Go to original source...
Go to PubMed...
- BoyerP, Lecrubier Z, Puech AJ, Aubin F. Treatment of negative symptoms in schizophrenia with amisulpride. Br J Psychiatry 1995, 166: 68-72.
Go to original source...
Go to PubMed...
- Paillére-Martinot ML, Lecrubier Y. Improvement of some schizophrenic deficit symptoms with low doses of amisulpride. Am J Psychiatry 1995, 152: 130-133.
Go to original source...
Go to PubMed...
- Speller JC, Barnes TR, Curson DA, Alberts JL. One-year, low-dose neuroleptic study of in-patients with chronic schizophrenia with negative symptomatology. Br J Psychiatry 1997, 171: 564-568.
Go to original source...
Go to PubMed...
- Danion JM, Rein W, Fleurot O. Improvement of schizophrenic patients with primary negative symptoms treated with amisulpride. Am J Psychiatry 1999, 156: 610-616.
Go to original source...
Go to PubMed...
- Loo H, Poirier-Littre MF et al. Amisulpride v.placebo in the medium-term treatment of the negative symptoms in schizophrenia. Br J Psychiatry 1997, 170: 18-22.
Go to original source...
Go to PubMed...
- Lecrubier Y, Bouhassira M, Olivier V. Olanzapine v. amisulpride and placebo in the treatment of negative symptoms and deficit states of chronic schizophrenia. Eur Psychopharmacology 1999: 9 (Suppl.5): 288.
Go to original source...
- Švestka J.Nová psychofarmaka: Ziprasidon - další antipsychotikum 2. generace. Psychiatrie 2000, 4: 255-263.
- Keck P, Buffenstein A, Ferguson J, Feighner J, Jaffe W. Ziprasidone in the acute exacerbation of schizophrenia and schizoaffective disorder. Psychopharmacology 1998, 140: 173-184.
Go to original source...
Go to PubMed...
- Daniel DG, Zimbroff DL, Potkin SG, Reeves KR, Harrigan EP. Ziprasidone in the acute exacerbation of schizophrenia and schizoaffective disorder. Neuropsychopharmacology 1999, 20: 491-505.
Go to original source...
Go to PubMed...
- Briefing Document for Zeldox capsules (ziprasidone HCL) for FDA Psychopharamacological Drugs Advisory Committee. Data on file, Pfizer 2000.
- Arato MO et al. Ziprasidone in the long term treatment of negative symptoms and prevention of exacerbation of schizophrenia. APA Annual Meeting, Toronto, Abstracts 1998, 152.
Go to original source...
- Hirsch S, PowerA, Kissling WA. A 28 week comparison of ziprasidone and haloperidol in outpatients with stable schizophrenia. Eur Neuropsychopharmacology 1999, 9 (Suppl.5): 264.
Go to original source...
- Harvey PD, Meltzer HY, Romano S. Improvement in cognition following a switch to open. label ziprasidone from olanzapine, risperidone and conventional antipsychotics (Abstracts). Int J Neuropsychopharmacology 2000, 3 (Suppl.1): 161.
Go to original source...
- Sallee FR, Kurlan R, Goetz CG, Singer H et al. Ziprasidone treatment of children and adolescents with Tourette syndrome: A pilot study. J Am Acad Child Adolesc Psychiatry 2000, 39: 292-299.
Go to original source...
Go to PubMed...
- Cooper SJ, Tweed J, Rainwalla J, Butler A, Welch C. A placebo-controlled comparison of zotepine versus chlorpromazine in patients with acute exacerbation of schizophrenia. Acta Psychiat Scand 2000, 101: 218-225.
Go to original source...
Go to PubMed...
- Cooper SJ, Butler A, Tweed J, Welch C, Rainwalla J. Zotepine in the prevention of recurrence: a randomised, double-blind, placebo-controlled study for chronic schizophrenia. Psychopharmacology 2000, 150: 237-243.
Go to original source...
Go to PubMed...
- Meyer-Lindenberg A, Gruppe H, Bauer U, Lis S, Krieger S, Gallhofer B. Improvement of cognitive function in schizophrenic patients receiving clozapine or zotepine: Results from a double.blind study. Pharmacopsychiatry 1997, 30: 35-42.
Go to original source...
Go to PubMed...
- Prakash A, Lamb HM, Bialer M, Conley RR et al. Zotepine. A review of its pharmacodynamic and phramacokinetic properties and therapeutic efficacy in the management of schizophrenia. CNS-Drugs. 1998, 9/2: 153-175.
Go to original source...