Psychiatr. pro Praxi, 2002; 6: 272-276

Násilné chování a možnosti jeho ovlivnění II. díl - Neurotransmitery a farmakoterapie

MUDr. Jan Vevera1, MUDr. Tereza Uhrová1, doc. MUDr. Roman Jirák CSc1, MUDr. Ilja Žukov CSc1, Mgr. Pavel Stopka Ph.D2, Ing. Mgr. Vojtěch Ort3
1 Psychiatrická klinika 1. LF UK a VFN Praha
2 Přírodovědecká fakulta UK, Laboratoř pro výzkum biodiverzity, Praha
3 Sdružení pro audit a řízení informačních systémů, Praha

Keywords: aggression, violence, biologic and environmental factors, prevalence, pharmacotherapy.

Published: December 31, 2002  Show citation

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Vevera J, Uhrová T, Jirák R, Žukov I, Stopka P, Ort V. Násilné chování a možnosti jeho ovlivnění II. díl - Neurotransmitery a farmakoterapie. Psychiatr. praxi. 2002;3(6):272-276.

Autoři popisují vliv neurotransmiterů na násilné chování. V článku jsou dále diskutovány léčebné strategie u akutního/perzistentního nepsychotického a akutního/perzistentního psychotického násilného chování pomocí antipsychotik, beta-blokátorů, benzodiazepinů a thymoprofylaktik.

Violent behavior and possibilities of its modification

Part II - Neurotransmitters and pharmacotherapy</bold></p> The authors describe the effect of neurotransmitters on aggressive behavior. Therapeutical strategies with antipsychotics, beta blockers, benzodiazepins and thymoprophylactics in management of acute persistent non psychotic and acute persistent psychotic violent behavior are discussed in this article.

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    References

    1. Volavka J. Neurotransmitters, Hormones, and Genes. In Neurobiology of Violence 2nd. ed. American Psychiatric Publishing, Washington, DC 2002, 45-81.
    2. Vevera J, Žukov I, Papežová H. Genetické koreláty násilného chování. Psychiatrie 2001; Suppl 2: 143-144.
    3. Volavka J, Mohr P, Nolan KA, Lachman HM. Agresivní chování při schizofrenii: nová genetická data. Biologické podklady psychických poruch. Grada 1997.
    4. New AS, Gelernter J, Yovell Y, Trestman RL, et al. Tryptophan hydroxylase genotype is associated with impulsive-aggression measures: a preliminary study. American Journal of Medical Genetics 1998; 81: 13-17. Go to original source...
    5. Gerra G, Zaimovic A, Avanzini P, Chittolini B, Giucastro G, Caccavari R, Palladino M, Maestri D, Monica C, Delsignore R, Brambilla F: Neurotransmitter-neuroendocrine responses to experimentally induced aggression in humans: influence of personality variable. Psychiatry Res 1997; 66: 33-43. Go to original source... Go to PubMed...
    6. Ratey JJ, Gordon A. The psychopharmacology of aggression: toward a new day. Psychopharmacol Bull 1993; 29: 65-73. Go to PubMed...
    7. Cases O, Seif I, Grimsby J, Gaspar P, Chen K, Pournin S, Muller U, Aguet M, Babinet C, Shih JC, De Maeyer E. Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA. Science 1995; 268:1763-1766. Go to original source... Go to PubMed...
    8. Brunner HG, Nelen M, Breakefield XO, Ropers HH, van Oost BA. Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A. Science 1993; 262: 578-580. Go to original source... Go to PubMed...
    9. af Klinteberg B, Schalling D, Edman G, Oreland L, Asberg M. Personality correlates of platelet monoamine oxidase (MAO) activity in female and male subjects. Neuropsychobiology 1987; 18: 89-96. Go to original source... Go to PubMed...
    10. Belfrage H, Lidberg L, Oreland L. Platelet monoamine oxidase activity in mentally disordered violent offenders. Acta Psychiatr Scand 1992; 85: 218-221. Go to original source... Go to PubMed...
    11. Schalling D, Edman G, Asberg M, Oreland L. Platelet MAO activity associated with impulsivity and aggressivity. Personality and Individual Differences 1988; 9: 597-605. Go to original source...
    12. Caspi A, McClay J, Moffitt TE, Mill J, Martin J, Craig IW, Taylor A, Poulton R. Role of genotype in the cycle of violence in maltreated children. Science. 2002; 297: 851-854. Go to original source... Go to PubMed...
    13. Kotler M, Barak P, Cohen H, Averbuch IE, Grinshpoon A, Gritsenko I, Nemanov L, Ebstein RP. Homicidal behavior in schizophrenia associated with a genetic polymorphism determining low catechol O-methyltransferase (COMT) activity. Am J Med Genet. 1999; 88: 628-633. Go to original source... Go to PubMed...
    14. Liou YJ, Tsai SJ, Hong CJ, Wang YC, Lai IC. Association analysis of a functional catechol-o-methyltransferase gene polymorphism in schizophrenic patients in Taiwan. Neuropsychobiology. 2001; 43: 11-14. Go to PubMed...
    15. Jones G, Zammit S, Norton N, et al. Aggressive behaviour in patients with schizophrenia is associated with catechol-O-methyltransferase genotype. Br J Psychiatry 2001; 179: 351-355. Go to original source... Go to PubMed...
    16. Egan MF, Goldberg TE, Kolachana BS, Callicott Jh, et al. Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proc Natl Acad Sci U S A. 2001;98: 6917-6922. Go to original source... Go to PubMed...
    17. Herken H, Erdal ME. Catechol-O-methyltransferase gene polymorphism in schizophrenia: evidence for association between symptomatology and prognosis. Psychiatr Genet 2001; 11: 105-109. Go to original source... Go to PubMed...
    18. Strous RD, Bark N, Parsia SS, Volavka J, Lachman HM. Analysis of a functional catechol O-methyltransferase gene polymorphism in schizophrenia: evidence for association with aggressive and antisocial behavior. Psychiatry Res 1997; 69: 71-77. Go to original source... Go to PubMed...
    19. Lachman HM, Nolan KA, Mohr P, Saito T, Volavka J. Association between catechol O-methyltransferase genotype and violence in schizophrenia and schizoaffective disorder. Am J Psychiatry 1998; 155: 835-837. Go to PubMed...
    20. Blass DM, Steinberg M, Leroi I, Lyketsos CG. Successful multimodality treatment of severe behavioral disturbance in a patient with advanced Huntington's disease. Am J Psychiatry. 2001; 158: 1966-1972. Go to original source... Go to PubMed...
    21. Crowner ML. Understending and treating violent psychiatric patients. Washington, D.C., American Psychiatric Press, Inc, 2000.
    22. Sobin P, Schneider L, McDermott H. Fluoxetine in the treatment of agitated dementia. Am J Psychiatry. 1989; 146: 1636. Go to original source...
    23. Greendyke RM, Kanter DR, Schuster DB, Verstreate S, Wootton J. Propranolol treatment of assaultive patients with organic brain disease. A double-blind crossover, placebo-controlled study. J Nerv Ment Dis. 1986; 174: 290-294. Go to original source... Go to PubMed...
    24. Citrome L, Volavka J, Czobor P, at al. Effects of clozapine, olanzapine, risperidone, and haloperidol on hostility among patients with schizophrenia. Psychiatr Serv. 2001; 52: 1510-1514. Go to original source... Go to PubMed...
    25. Cowdry RW, Gardner DL. Pharmacotherapy of borderline personality disorder: alprazolam, carbamazepine, trifluoroperazine, and trnilcypromine. Arch Gen Psychiatry 1987; 45: 111-119. Go to original source... Go to PubMed...
    26. Marin DB, Greenwald BS. Carbamazepine for aggressive agitation in demented patients during nursing care. Am J Psychiatry. 1989; 146: 805. Go to original source... Go to PubMed...
    27. Patterson JF. A preliminary study of carbamazepine in the treatment of assaultive patients with dementia. J Geriatr Psychiatry Neurol. 1988; 1: 21-23. Go to original source... Go to PubMed...
    28. Patterson JF. Carbamazepine for assaultive patients with organic brain disease. Psychosomatics. 1987; 28: 579-581. Go to original source... Go to PubMed...
    29. Wilcox J. Divalproex sodium in the treatment of aggressive behavior. Ann Clin Psychiatry. 1994; 6: 17-20. Go to original source... Go to PubMed...
    30. Brennan PA, Grekin ER, Mednick SA. Maternal smoking during pregnancy and adult male criminal outcomes. Arch Gen Psychiatry. 1999; 56: 215-219. Go to original source... Go to PubMed...
    31. Dostal T, Zvolsky P. Antiaggressive effect of lithium salts in severe mentally retardet adolescents. International Psychofarmakology. 1970; 5: 203-207. Go to original source...
    32. Mejia J, Ervin F, Baker G, Palmour R. Monoamine oxidase inhibition during brain development induces pathological aggressive behavior in mice. Biol Psychiatry. 2002; 52: 811-822. Go to original source... Go to PubMed...
    33. Fowler JS, Volkow ND, Wang GJ, Pappas N, Logan J, MacGregor R, Alexoff D, Shea C, Schlyer D, Wolf AP, Warner D, Zezulkova I, Cilento R. Inhibition of monoamine oxidase B in the brains of smokers. Nature. 1999; 379: 733-736. Go to original source... Go to PubMed...
    34. Volavka J. Neurobiology of Violence, Washington, D.C., American Psychiatric Press, Inc., 1995.

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