Psychiatr. pro Praxi, 2003; 6: 263-266

Farmakoterapie u mentální anorexie

MUDr. Renata Zámečníková, doc. MUDr. Michal Hrdlička CSc
Dětská psychiatrická klinika 2. LF UK a FN v Motole, Praha

Keywords: eating disorders, anorexia nervosa, pharmacotherapy, antidepressants, neuroleptics.

Published: December 31, 2003  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Zámečníková R, Hrdlička M. Farmakoterapie u mentální anorexie. Psychiatr. praxi. 2003;4(6):263-266.

Mentální anorexie (MA) je porucha příjmu potravy s vysokou prevalencí, chronickým průběhem a vysokou mortalitou, která postihuje především dospívající dívky a mladé ženy. Základem terapie MA je nutriční a režimová terapie doplněná psychoterapií. Farmakoterapie představuje možný terapeutický přístup u některých pacientek. V centru pozornosti stojí moderní antidepresiva, jejichž užití se doporučuje u anorektických pacientek s depresivní nebo obsedantně kompulzivní symptomatikou a v prevenci relapsu onemocnění. Neuroleptika, zejména atypická, jsou další terapeutickou možností u MA.

Pharmacotherapy in Anorexia Nervosa

Anorexia nervosa (AN) is an eating disorder with high prevalence, chronic course, and high mortality. It affects primarily adolescent girls and young women. The basic therapy for AN involves nutritional therapy and behavioral modification combined with psychotherapy. Pharmacotherapy could be additional therapeutic approach in some patients. Modern antidepressants are considered to be a useful therapeutic tool in anorectic patients with depressive or obsessive compulsive symptoms as well as in relapse prevention. Neuroleptics, especially atypical, are another therapeutic option in AN.

Download citation

References

  1. Attia E, Haiman C, Walsh BT, Fater SR. Does fluoxetine augment the inpatient treatment of anorexia nervosa? Am. J. Psychiatry 1998; 155: 548-551. Go to original source... Go to PubMed...
  2. Bianco G, Claps M, Marinucci S, Montecchi F. Use of risperidone in adolescent anorexia nervosa. Ital.J.Psychiatry Behav. Sci., 2000; 10 (2): 50-52.
  3. Birmingham CL, Goldner EM, Bakan R, Controlled trial of zinc supplementation in anorexia nervosa Int. J. Eat. Dis. 1994; 15 (3): 251-255. Go to original source...
  4. Boachie A, Goldfield GS, Spettigue W. Olanzapine use as an adjunctive treatment for hospitalized children with anorexia nervosa: case reports. Int. J. Eat. Disord. 2003; 33 (1): 98-103. Go to original source... Go to PubMed...
  5. Cassano GB, Monisti M, Pini S, Rotundo A, Banti S, Borri C, Camilleri V, Mauri M. Six-month open trial of haloperidol as an adjunctive treatment for anorexia nervosa: a preliminary report. Int. J. Eat. Disord. 2003; 33 (2): 172-177. Go to original source... Go to PubMed...
  6. Ercan ES, Copkunol H, Cykoethlu S, Varan A. Olanzapine treatment of an adolescent girl with anorexia nervosa. Hum. Psychopharmacol. 2003; 18 (5): 401-403. Go to original source... Go to PubMed...
  7. Faltus F. Novinky v etiopatogenezi a farmakoterapii poruch příjmu potravy. Psychiatrie, 2001; (Suppl. 2): 30.
  8. Faltus F. Farmakoterapie poruch příjmu potravy. In: Krch, FD. a kol., Poruchy příjmu potravy. Praha, Grada Publishing, 1999: 157-165.
  9. Fassino S, Leombruni P, Daga G, Brustolin A, Migliaretti G, Cavallo F, Rovera G. Efficacy of citalopram in anorexia nervosa: a pilot study. Eur. Neuropsychopharmacol. 2002; 12 (5): 453-459. Go to original source... Go to PubMed...
  10. Halmi KA. Anorexia nervosa. In Kaplan HI, Freedman AM, Sadock BJ (eds). Comprehensive Textbook of Psychiatry III. Baltimore: Williams and Wilkins, 1980: 1882-1891.
  11. Halmi KA. Eating disorders: Anorexia nervosa, bulimia nervosa and obesity. In: American Psychiatric Press Textbook of Psychiatry. Third edition, 1999: 983-1002.
  12. Kaye WH, Nagata T, Weltzin TE, Hsu LK, Sokol MS, McConaha C, Plotnicov KH, Weise J, Deep D. Double-blind placebo-controlled administration of fluoxetine in restricting and restricting-purging-type anorexia nervosa. Biol. Psychiatry, 2001; 49, 7: 644-652. Go to original source... Go to PubMed...
  13. Kim SS. Role of fluoxetine in anorexia nervosa, Ann.Pharmacother. 2003; 37 (6): 890-892. Go to original source... Go to PubMed...
  14. Lucas AR. Anorexia nervosa and bulimia nervosa. In Lewis M. Child and adolescent psychiatry. Baltimore: Williams, Wilkins, 1996: 586-593.
  15. Malina A, Gaskill J, McConaha C, Frank GK, LaVia M, Scholár L, Kaye WH. Olanzapin treatment of anorexia nervosa: a retrospective study. Int. J. Eat. Disord. 2003; 33 (2): 234-237. Go to original source... Go to PubMed...
  16. Mehler C, Wewetzer C, Schulze U, Warnke A, Theisen F, Dittmann RW. Olanzapine in children and adolescents with chronic anorexia nervosa. A study of five cases. Eur.Child Adolesc.Psychiatry, 2001; 10 (2): 151-157. Go to original source... Go to PubMed...
  17. Mitchell JE, de-Zwaan M, Roerig JL. Drug therapy for patients with eating disorders. Curr.Drug Target CNS Neurol.Disord. 2003; 2 (1): 17-29. Go to original source... Go to PubMed...
  18. Powers PS, Santana CA, Bannon YS. Olanzapine in treatment of anorexia nervosa: an open label trial. Int. J. Eat. Disord. 2002; 32 (2): 146-154. Go to original source... Go to PubMed...
  19. Ruggiero GM, Laini V, Mauri MC, Ferrari VM, Clemente A, Lugo F, Mantero M, Redaelli G, Zappulli D, Cavagnini F. A single blind comparison of amisulpride, fluoxetine and clomipramine in treatment of restricting anorectics. Prog. Neuropsycopharmacol. Biol. Psychiatry, 2001, 25 (5): 1049-1059. Go to original source... Go to PubMed...
  20. Santonastaso P, Friederici S, Favaro A. Sertralin in the treatment of restricting anorexia nervosa: an open controlled trial. J. Child Adolesc. Psychopharmacol., 2001; 11, 2: 143-150. Go to original source... Go to PubMed...
  21. Su JC, Birmingham CL. Zinc supplementation in the treatment of anorexia nervosa. Eat.Weight.Disord. 2002; 7 (1): 20-22. Go to original source... Go to PubMed...
  22. Vandereycken W, Pierloot R. Combining drugs and behavior therapy in anorexia nervosa: A double-blind placebo/pimozide study. In: L Darby, E Garfinkel, M Garner, V Coscina (ed) Anorexia Nervosa: Recent Developments in Research, Alan R. Liss, New York, 1983: 365-375.
  23. Vandereycken W. Neuroleptics in the short-term treatment of anorexia nervosa: double-blind placebo-controlled study with sulpiride. Br. J. Psychiatry, 1984; 144: 288-292. Go to original source... Go to PubMed...
  24. Walsh BT, Devlin MJ. Psychopharmacology of anorexia nervosa, bulimia nervosa and binge eating. In: Psychopharmacology. The Fourth Generation of Progress. Electronic version of this book. ACNP, 2000.
  25. Yager J, Andersen A, Devlin M, Egger H, Herzog D, Mitchell J, Powers P, Yates A, Zerbe K. Treatment of patients with eating disorders. In: American Psychiatric Association: Practice Guidelines for the Treatment of Psychiatric Disorders; Compendium 2002: 697-766.
  26. Zámečníková R, Hrdlička M. Farmakoterapie u mentální anorexie. Přednáška na IV. sjezdu České psychiatrické společnosti, 13.-16. 6. 2002.




Psychiatry for Practice

Madam, Sir,
please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

I declare:

  1. that I have met the above instruction
  2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited


No

Yes

If your statement is not true, please be aware
that brings the risk of danger to their health or the health of others.