Psychiatr. pro Praxi, 2007; 8(6): 266-268

Olanzapine and pregnancy

MUDr. Marek Zelman1, MUDr. Lenka Jenčová2
1 Psychiatrická nemocnica Hronovce
2 PO Banská Bystrica

The pharmacotherapy of any disease in pregnancy brings potential risk of negative effect of drugs for fetus. In keeping with risk of an exacerbation of psychotic disorders we often decide for continual therapy despite a possible menace for an unborn child. Our article summarizes the literary sources about using of olanzapine in pregnancy and shows three case reports.

Keywords: olanzapine, pregnancy, risk-benefit

Published: January 15, 2008  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Zelman M, Jenčová L. Olanzapine and pregnancy. Psychiatr. praxi. 2007;8(6):266-268.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Abilify, Abilify Discmelt Prescribing Information; www.fda.gov.
    2. Arora M, Praharaj SK. Meningocele and ankyloblepharon following in utero exposure to olanzapine. Eur Psychiatry 2006; 21(5): 345-346. Go to original source... Go to PubMed...
    3. Bazire S. Psychotropics in problem areas. In: Bazire S: Psychotropis Drug Directory 2005, The professionals pocket handbook and aide memoire. Fivepin Limited; Salisbury 2005.
    4. Bennedsen BE et al. Preterm birth and intrauterine growth retardation amoung children of women with schizophrenia, Br J Psychiatry 1999, 175: 239-245. Go to original source... Go to PubMed...
    5. Clozaril Prescribing Information; www.fda.gov.
    6. Croke SJ, Buist AE, Norman TR et al. Presence of olanzapine in breast milk. Int J of Neuropsychopharmacol 2002; 5(3): 243-247. Go to original source...
    7. Dickson RA, Dawson DT. Olanzapine and pregnancy. Canadian J Psychiatry 1998; 43(2): 196-197.
    8. Geodon, Deodon for injection prescribing information; www.fda.gov.
    9. Horáček J, Seifertová D. Terapie antipsychotiky v těhotenství. Psychiatrie 2002; 6(Suppl. 2): 4-8.
    10. Iqbal MM et al. Effects of antimanic mood-stabilizing drugs on fetuses, neonates, and nursing infants. South Med J 2001; 94(3): 305-322. Go to original source...
    11. Kirchheiner J, Berghöfer A, Bolk-Weischedel D. Healthy outcome under olanzapine treatment in a pregnant woman. Pharmacopsychiatry 2000; 33: 78-80. Go to original source... Go to PubMed...
    12. Koren G et al. Use of atypical antipsychotics during pregnancy and the risk of neural tube defects in infants. Am J Psychiatry Jan 2002; 159: 136-137. Go to original source... Go to PubMed...
    13. Lilly Worldwide Pharmacovigilance Safety Database 2001; Data on file.
    14. Lim LM. Olanzapine and pregnancy. Aust NZ J Psychiatry 2001; 35(6): 856-857. Go to original source...
    15. Littrell KH, Johnson CG, Peabody CD, et al. Antipsychotics during pregnancy. Am J Psychiatry 2000; 157: 1342. Go to original source... Go to PubMed...
    16. Malek-Ahmadi P. Olanzapine in pregnancy. Annals of Pharmacotherapy 2001; 35: 1294-1295. Go to original source... Go to PubMed...
    17. McKenna K et al. Pregnancy out come of women using atypical antipsychotic drugs: a prospective comparative study. J Clin Psychiatry 2005; 66: 444-449. Go to original source... Go to PubMed...
    18. Mendhekar DN, War L, Sharma JB, Jiloha RC. Olanzapine and pregnancy. Pharmacopsychiatry 2002; 35(3): 122-123. Go to original source... Go to PubMed...
    19. Mohr P et al. Psychické poruchy v gravidite a laktaci. In: Seifertová D, Praško J, Höschl C. Postupy v léčbe psychických poruch. První vydání, Academia Medica Pragensis, Praha 2004.
    20. Nagy A, Tenyi T, Lenard K et al. Olanzapin es terhesseg. Orvosi Hetilap 2001; 142(3): 137-138. Go to PubMed...
    21. Neumann NU, Frasch K. Olanzapine and pregnancy. 2 case reports. Nervenarzt. 2001; 72(11): 876-878. Go to original source... Go to PubMed...
    22. Patton WS et al. Antipsychotic medication during pregnancy and lactation in women with schizophrenia: evaluating the risk. Can J Psychiatry 2002; 47: 959-965. Go to original source... Go to PubMed...
    23. Risperdal, Risperdal M-tab. Prescribing Information; www.fda.gov.
    24. Seroquel prescribing information; www.fda.gov.
    25. Spyropoulou AC, Zervas IM, Soldatos CR. Hip dysplasia following a case of olanzapine exposed pregnancy: a questionable association. Arch Womens Ment Health 2006; 9(4): 219-222. Go to original source... Go to PubMed...
    26. Wilcox AJ. Early pregnancy. In: Reproductive and perinatal epidemiology. Kiely M, ed. Boca Raton: CRC Press; 1991: 69.
    27. Wisner KL et al. Risk-benefit decision making for treatment of depression during pregnancy. Am J Psychiatry 2000; 157: 1933-1940. Go to original source... Go to PubMed...
    28. Yaeger D et al. Atypical antipsychotics in the treatment of schizophrenia during pregnancy and the postpartum. Am J Psychiatry 2006; 163: 12. Go to original source... Go to PubMed...
    29. Zyprexa, Zyprexa Zydis, Zyprexa intramuscular prescribing information; www.fda.gov.

    Return to the content


    Psychiatry for Practice

    Madam, Sir,
    please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
    Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

    I declare:

    1. that I have met the above instruction
    2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited

    No
    Yes

    If your statement is not true, please be aware
    that brings the risk of danger to their health or the health of others.