Psychiatr. pro Praxi, 2009; 10(3): 130-134

Complex antidepressant effect and pain

MUDr. Marek Páv
Psychiatrická léčebna Horní Beřkovice

Pain and depression are pathological states influenced by serotonergic and noradrenergic system functioning. In the treatment of both

states are used drugs, affecting both neurotransmitter systems. In the chronic pain pathogenesis besides neuronal system changes takes

place also glial cell activation, which can endure acute pain stimulus and participate in the pain chronification. Antidepressant treatment

is affecting depressive syndrome and pain affective and cognitive component due neuroplastic processes modulation. Inflammatory

mediators can activate stress axis and influence neurotransmitter metabolism during chronic pain states, antidepressants diminish

inflammatory molecule production on the periphery and in the central nervous system, uncoupling thus stress axis activation.

Keywords: pain, depression, antidepressant, microglia, astrocyte, cytokine, neuroplasticity.

Published: May 1, 2009  Show citation

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Páv M. Complex antidepressant effect and pain. Psychiatr. praxi. 2009;10(3):130-134.
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