Psychiatr. pro Praxi, 2010; 11(1): 15-17

The combination of antipsychotics in the treatment of schizophrenia

doc.MUDr.Radovan Přikryl, Ph.D., PhDr.Hana Přikrylová-Kučerová, Ph.D.
Psychiatrická klinika LF MU a FN Brno

Use of combined antipsychotics for patients with treatment resistant schizophrenia is common practice in psychiatry. For patients who

have not responded to non-clozapine monotherapy, and are unable to use or unresponsive to clozapine, combination therapy with other

antipsychotics is another alternative.

Keywords: antipsychotics, combination, schizophrenia

Published: January 1, 2010  Show citation

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Přikryl R, Přikrylová-Kučerová H. The combination of antipsychotics in the treatment of schizophrenia. Psychiatr. praxi. 2010;11(1):15-17.
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References

  1. Kane J, Honigfeld G, Singer J, Meltzer H. Clozaril Collaborative Study Group. Clozapine for the treatment-resistant schizophrenic. Arch Gen Psychiatry 1988; 45: 789-796. Go to original source... Go to PubMed...
  2. Turkington D, Kingdon D, Weiden PJ. Cognitive behavior therapy for schizophrenia. Am J Psychiatry 2006; 163: 365-373. Go to original source... Go to PubMed...
  3. Davis JM, Chen N, Glick ID. A meta-analysis of the efficacy of second-generation antipsychotics. Arch Gen Psychiatry 2003; 60: 553-564. Go to original source... Go to PubMed...
  4. Švestka, J. Clozapin. Prototyp antipsychotik nové generace. Maxdorf Jesenius, 1998: 89-105.
  5. Tiihonen J, Lonqvist J, Wahlbeck K, et al. 11-year followup of mortality in patients with schizophrenia: a population-based cohort study (FIN11-study). Lancet, published online July 13, 2009.
  6. Freudenreich O, Goff DC. Antipsychotic combination therapy in schizophrenia: a review of efficacy and risks of current combinations. Acta Psychiatr Scand 2002; 106: 323-330. Go to original source... Go to PubMed...
  7. Dunkley MJ, Reveley MA. Successful treatment of refractory schizophrenia with combined olanzapine and quetiapine in a patient with a prolactin secreting pituitary microademona. J Psychopharmacology 2005; 19: 97-101. Go to original source... Go to PubMed...
  8. Duggal SH. Aripiprazole-olanzapine combination for the treatment of schizophrenia. Canadian J Psych 2004; 49: 151. Go to original source... Go to PubMed...
  9. Lerner V, Bergman J, Borokhov A, et al. Augmentation with amisulpride for schizophrenic patients nonresponsive to antipsychotic monotherapy. Clin Neuropharmacol. 2005; 28: 66-71. Go to original source... Go to PubMed...
  10. Zink M, Henn FA, Thome J. Combination of amisulpride and olanzapine in treatment-resistant schizophrenia psychoses. Eur Psychiatry 2004; 19: 56-58. Go to original source... Go to PubMed...
  11. Lerner V, Chudakova B, Kravets S, Polyakova I. Combined use of risperidone and olanzapine in the treatment of patients with resistant schizophrenia: a preliminary case series report. Clin Neuropharmacol. 2000; 23: 284-286. Go to original source... Go to PubMed...
  12. John V, Rapp M, Pies R. Aggression, agitation, and mania with olanzapine (Letter). Can J Psychiatry 1998; 43: 1054.
  13. Seger A, Lamberti JS. Priapism associated with polypharmacy (Letter). J Clin Psychiatry 2001; 62: 128. Go to original source... Go to PubMed...
  14. Nelson MW, Reynolds RR, Kelly DL, Conley RR. Adjunctive quetiapine decreases symptoms of tardive dyskinesia in a patient taking risperidone. Clin Neuropharmacol. 2003; 26: 297-298. Go to original source... Go to PubMed...
  15. Bozikas VP, Deseri C, Pitsavas S, Karavatos A. Anti-aggressive action of combined risperidone and quetiapine in a patient with schizophrenia (Letter). Can J Psychiatry 2003; 48: 426-427. Go to original source... Go to PubMed...
  16. Chue P, Welch R, Snaterse M. Combination risperidone and quetiapine therapy in refractory schizophrenia (Letter). Can J Psychiatry 2001; 46: 86-87.
  17. Jones GH., ,Clozapine effect" without the blood tests. Progress in neurology and psychiatry 2002; 6: 32.
  18. O'Shea M, Sazhin V, Collins A. Ventricular ectopics during crossover of atypical antipsychotics. Aus New Zealand J Psychiatry 2003; 37: 773-774. Go to original source... Go to PubMed...
  19. Hedges DW, Jeppson KG. New-onset seizure associated with quetiapine and olanzapine. Ann Pharmacother. 2002; 36: 437-439. Go to original source... Go to PubMed...
  20. DeQuardo JR. Worsened agitation with aripiprazole: adverse effect of dopamine partial agonism? (Letter). J Clin Psychiatry 2004; 65: 132-133. Go to original source... Go to PubMed...
  21. Ramaswamy S, Vijay D, William M, et al. Aripiprazole possibly worsens psychosis. Int Clin Psychopharmacol. 2004; 19: 45-48. Go to original source... Go to PubMed...
  22. Reeves RR, Mack JE. Worsening schizoaffective disorder with aripiprazole (Letter). Am J Psychiatry 2004; 16: 1308. Go to original source... Go to PubMed...
  23. Paton C, Whittington, Barnes TR. Augmentation with a second antipsychotic in patient with schizophrenia who partially respond to clozapine. J Clin Psychopharmacol 2007; 27: 198-204. Go to original source... Go to PubMed...
  24. Taylor DM, Smith L. Augmentation of clozapine with a second antipsychotic - a meta-analysis of randomized, placebocontrolled studies, Acta Psychiatr Scand 2009; 119: 419-425. Go to original source... Go to PubMed...
  25. Braga RJ, Petrides G. The combined use of electroconvulsive therapy and antipsychotics in patients with schizophrenia. J ECT 2005; 21: 75-83. Go to original source... Go to PubMed...
  26. Češková E, Kašpárek T, Ondrušová M. Kombinace antipsychotik. Česká a slovenská psychiatrie 2001; 6: 286-290.
  27. Basan A, Kissling W, Leucht S. Valproate as an adjunct to antipsychotics for schizophrenia: a systematic review of randomized trials. Schizophr Res. 2004; 70: 33-37. Go to original source... Go to PubMed...
  28. Citrome L, Casey DE, Daniel DG, et al. Adjunctive divalproex and hostility among patients with schizophrenia receiving olanzapine or risperidone. Psychiatr Serv. 2004; 55: 290-294. Go to original source... Go to PubMed...
  29. Kremer I, Vass A, Gorelik I, et al. Placebo-controlled trial of lamotrigine added to conventional and atypical antipsychotics in schizophrenia. Biol Psychiatry 2004; 56: 441-446. Go to original source... Go to PubMed...
  30. Thomas R, Howe V, Foister K, Keks N. Adjunctive lamotrigine in treatment-resistant schizophrenia. Int J Neuropsychopharmacol. 2006; 9: 125-127. Go to original source... Go to PubMed...
  31. Skotáková S, Ustohal L, Přikryl R, Navrátilová P. Léčba sluchových halucinací pomocí repetitivní transkraniální magnetické stimulace (rTMS) aplikované na oblast temporoparietálního kortexu: kazuistické sdělení. Psychiatrie 2007; 11: 33.
  32. Jones C, Cormac I, Silveira da Mota Neto JI, Campbell C. Cognitive behaviour therapy for schizophrenia. Cochrane Database Syst Rev. 2004; 4: CD000524. Go to original source... Go to PubMed...
  33. Češková E, Šulcová A. Antipsychotika na počátku třetího tisíciletí. Trendy ve farmakoterapii 2003; 39: 23-31.




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