Psychiatr. pro Praxi, 2010; 11(2): 52-55

The specificity of pharmacotherapy in gerontopsychiatry

doc.MUDr.Roman Jirák, CSc.
Psychiatrická klinika 1. LF UK Praha

Pharmacotherapy in old age requires specific approach. We can see more frequently lower portion of water in body tissue in comparison

with younger age. On the other hand there is usually higher amount of fat. Older people suffer often from different disorders that alter

pharmacokinetics (for instance renal or hepatic insufficiency, chronic constipation and others). There is one general principle, especially

in psychopharmacotherapy – „start low, go slow”.

Author analyses particular groups of psychopharmaceutics and introduces the specifics of their use in old age persons.

Keywords: adverse events, antidepressants, antipsychotics, cognitive drugs, gerontopsychiatry, pharmacokinetics

Published: March 1, 2010  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Jirák R. The specificity of pharmacotherapy in gerontopsychiatry. Psychiatr. praxi. 2010;11(2):52-55.
Download citation

References

  1. Květina J. Gerontofarmakologie. In Kalvach Z, Zadák Z, Jirák R, a kol. Geriatrie a gerontologie. Grada Publishing, Praha 2004: 365-375.
  2. Crone C. Elder people and new medicine. Int Journ Pharmaceut Med. 1998; 12: 207-210.
  3. Hegyi L. Klinické aspekty užívania liekov staršími luďmi. In Kalvach Z, Zadák Z, Jirák R, a kol. Geriatrie a gerontologie. Grada Publishing, Praha 2004: 375-382.
  4. Linden M, Bär T, Helmchen H. Prevalence and appropriateness of psychotropic drug use in old age: results from the Berlin Aging Study (BASE). Internat Psychogeriatrics, 2004; 16: 461-480. Go to original source... Go to PubMed...
  5. Raboch J, Jirák R, Paclt I. Psychofarmakologie pro praxi. 2., rozšířené a přepracované vydání. Triton, Praha 2007: 167.
  6. McLean AJ, Le Couteur G. Aging biology and geriatric clinical pharmacology. Pharmacol Reviews 2004; 56(2): 163-184. Go to original source... Go to PubMed...
  7. Fisk DM, Cooper JW, Wade WE, et al. Updating the Beers criteria for potentially inappropriate medication use in older adults. Arch Intern Med 2003; 163: 2716-2724. Go to original source... Go to PubMed...
  8. Jirák R, Koukolík F. Demence. Galen, Praha, 2004: 335.
  9. Winblad B, Jones RW, Wirth Y, et al. Memantine in moderate to severe Alzheimer´s disease: a meta-analysis of randomised clinical trials. Dement Geriatr Cogn Disord 2007; 24: 20-27. Go to original source... Go to PubMed...
  10. Caltagirone C, Bianchetti A, Di Luca M, et al. Guidelines for the treatment of Alzheimer´s disease from the Italian Association of Psychogeriatrics. Drugs & Aging 2005; 22(Suppl. 1): 1-26. Go to original source... Go to PubMed...
  11. Winblad B, Cummings J, Andreasen N, et al. A six-month double-blind, randomized, placebo-controlled study of a transdermal patch in Alzheimer´s disease - rivastigmine patch versus kapsule. Intern Journ Geriat Psychiatry 2007; 22: 456-467. Go to original source... Go to PubMed...




Psychiatry for Practice

Madam, Sir,
please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

I declare:

  1. that I have met the above instruction
  2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited


No

Yes

If your statement is not true, please be aware
that brings the risk of danger to their health or the health of others.