Psychiatr. pro Praxi, 2010; 11(3): 103-106

Pharmacotherapy in hospitalized depressed patients

prof.MUDr.Eva Češková, CSc.

Psychiatrická klinika LF MU a FN Brno

Nowadays, we have at our disposal a large spectrum of antidepressants; however, only in a part of patients a remission is achieved. One of

the reasons, undoubtedly, is the fact that depressive disorder represents a very heterogeneous group. We have no robust markers of the

disease and the diagnosis is based on the number and to a certain degree on the severity of the symptoms. In clinical trials an important

inclusion criterion is a score of the evaluation scales. In a common, especially out-patient clinical practice, we are using a more general

evaluation of the treatment effect. Among newer ADs there are differences not only in tolerability but also efficacy. Effect of AD again

placebo is increasing with the severity of depression. These findings have not yet been taking into consideration in the contemporary

recommended guidelines.

Keywords: severe depression, diagnosis, treatment, efficacy, tolerability

Published: July 1, 2010  Show citation