Psychiatr. pro Praxi, 2010; 11(3): 110-114

Pathophysiology of pain and depression

doc.RNDr.Anna Yamamotová, CSc., prof.MUDr.Hana Papežová, CSc.
UK v Praze, Ústav normální, patologické a klinické fyziologie 3. LF a Psychiatrická klinika 1. LF, Praha

Patients with chronic pain suffer more than just from the pain. Immobilization, isolation, lost of social contacts, depression and catastrophic

thinking considerably changes their quality of life. Frequent co-morbidity of chronic pain and depression arise a question of

overlapping pathophysiological mechanisms. This review discusses different mechanisms of pain and clinical pain representation in the

human brain. The treatment of chronic pain with adjuvant analgesics is briefly mentioned.

Keywords: chronic pain, peripheral and central mechanisms of pain, depression, pharmacological treatment

Published: July 1, 2010  Show citation

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Yamamotová A, Papežová H. Pathophysiology of pain and depression. Psychiatr. praxi. 2010;11(3):110-114.
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