Psychiatr. pro Praxi, 2010; 11(3): 117-121

Repetitive transcranial magnetic stimulation in the treatment of depression

MUDr.Bc.Libor Ustohal
Psychiatrická klinika LF MU a FN Brno

This article concerns with the use of repetitive transcranial magnetic stimulation (rTMS) in the treatment of depression. Its principal is to

influence the brain using variable magnetic field. This method is safe and well tolerated with the minimum of side-effects. We have most

experiences in psychiatry just in the treatment of depression. It is documented that rTMS influences cortical excitability and metabolic

activity of neuronal cells. It has been conducted a lot of studies of its efficacy in the treatment of depression, which can be divided into

three generations. Their outcomes were summarized in several metaanalyses. Last metaanalyses confirm that rTMS is a promising therapeutic

method, although a lot of questions concerning especially with an exact mechanism of its action, optimal stimulation parameters

and a selection of optimal patients, remain unanswered.

Keywords: depression, principle of rTMS, contraindications of rTMS, antidepressive effect of rTMS, efficacy of rTMS

Published: July 1, 2010  Show citation

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Ustohal L. Repetitive transcranial magnetic stimulation in the treatment of depression. Psychiatr. praxi. 2010;11(3):117-121.
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References

  1. Daskalakis ZJ, Levinson AJ, Fitzgerald PB. Repetitive transcranial magnetic stimulation for major depressive disorder: a review. Can J Psychiatry 2008; 53(9): 555-566. Go to original source... Go to PubMed...
  2. Burt T, Lisanby H, Sackeim H. Neuropsychiatric applications of transcranial magnetic stimulation: a meta-analysis. Int J Neuropsychopharmacol 2002; 5(1): 73-103. Go to original source... Go to PubMed...
  3. Loo CK, Mitchell PB, McFarquhar TF, et al. A sham-controlled trial of the efficacy and safety of twice-daily rTMS in major depression. Psychol Med 2007; 37(3): 341-349. Go to original source... Go to PubMed...
  4. Tuček J. Transkraniální magnetická stimulace a její možnosti. Psychiat pro Praxi 2002; 3: 121-123.
  5. Kopeček M, Bareš M. Repetitivní transkraniální magnetická stimulace (rTMS) v léčbě deprese. Přehled publikovaných studií. Psychiatrie 2004; 8(2): 117-132.
  6. Rau A, Grossheinrich N, Palm O, et al. Transcranial and deep brain stimulation approaches as treatment for depression. Clin EEG Neurosci 2007; 38(2): 105-115. Go to original source... Go to PubMed...
  7. Přikryl R, Kučerová H. Occurence of epileptic paroxysm during repetitive transcranial magnetic stimulation treatment. J Psychopharmacol 2005; 19(3): 313. Go to original source... Go to PubMed...
  8. Loo C, Sachdev P, Elsayed H, et al. Effects of a 2- to 4-week course of repetitive transcranial magnetic stimulation (rTMS) on neuropsychologic functioning, electroencephalogram, and auditory threshold in depressed patients. Biol Psychiatry 2001; 49(7): 615-623. Go to original source... Go to PubMed...
  9. Ella R, Zwanzger P, Stampfer R, et al. Switch to mania after slow rTMS of the right prefrontal cortex. J Clin Psychiatry 2002; 63(3): 249. Go to original source... Go to PubMed...
  10. Zwanzger P, Ella R, Keck M, et al. Occurrence of delusions during repetitive transcranial magnetic stimulation (rTMS) in major depression. Biol Psychiatry 2002; 51(7): 602-603. Go to original source... Go to PubMed...
  11. Bickford R, Guidi M, Fortesque P, Swenson M. Magnetic stimulation of human peripheral nerve and brain: response enhancement by combined magnetoelectrical technique. Neurosurgery 1987; 20(1): 110-116. Go to original source... Go to PubMed...
  12. Klein E, Kreinin I, Chistyakov A, et al. Therapeutic efficacy of right prefrontal slow repetitive transcranial magnetic stimulation in major depression: a double-blind controlled study. Arch Gen Psychiatry 1999; 56(4): 315-320. Go to original source... Go to PubMed...
  13. Fitzgerald PB, Brown TL, Marston NA. Transcranial magnetic stimulation in the treatment of depression: a doubleblind, placebo-controlled trial. Arch Gen Psychiatry 2003; 60(10): 1002-1008. Go to original source... Go to PubMed...
  14. Post A, Keck ME. Transcranial magnetic stimulation as a therapeutic tool in psychiatry: what we know about the neurobiological mechanisms? J Psychiatr Res 2001; 35(4): 193-215. Go to original source... Go to PubMed...
  15. Loo C. TMS in the treatment of major depressive disorder. In: Wassermann EM, Epstein CM, Ziemann U, et al. (eds.). The Oxford handbook of transcranial stimulation. Oxford University Press 2008: 633-660.
  16. Müller MB, Toschi N, Kresse AE, et al. Long-term repetitive transcranial magnetic stimulation increases the expression of brain-derived neurotrophic factor and cholecystokinin mRNA, but not neuropeptide tyrosine mRNA in specific areas of rat brain. Neuropsychopharmacol 2000; 23(2): 205-215. Go to original source... Go to PubMed...
  17. Post A, Müller MB, Engelmann M, Keck ME. Repetitive transcranial magnetic stimulation in rats: evidence for a neuroprotective effect in vitro and in vivo. Eur J Neurosci 1999; 11(9): 3247-3254. Go to original source... Go to PubMed...
  18. Funamizu H, Ogiue-Ikeda M, Mukai H, et al. Acute repetitive transcranial magnetic stimulation reactivates dopaminergic system in lesion rats. Neurosci Lett 2005; 383(1-2): 77-81. Go to original source... Go to PubMed...
  19. Speer AM, Kimbrell T, Wassermann E, et al. Baseline absolute blood flow measured with oxygen-15 PET predicts differential antidepressants response to 1 Hz versus 20 Hz rTMS. American Psychiatric Association Meeting 1999, New Research, abstract 191, 115.
  20. Kimbrell TA, Little JT, Dunn RT, et al. Frequency dependence of antidepressant response to left prefrontal repetitive transcranial magnetic stimulation (rTMS) as a function of baseline cerebral glucose metabolism. Biol Psychiatry 1999; 46(12): 1603-1613. Go to original source... Go to PubMed...
  21. Speer AM, Kimbrell TA, Wassermann EM, et al. Opposite effects of high and low frequency rTMS on regional brain activity in depressed patients. Biol Psychiatry 2000; 48(12): 1133-1141. Go to original source... Go to PubMed...
  22. Fitzgerald PB, Benitez J, de Castella A, et al. A randomized, controlled trial of sequential bilateral repetitive transcranial magnetic stimulation for treatment-resistant depression. Am J Psychiatry 2006; 163(1): 88-94. Go to original source... Go to PubMed...
  23. Chen R, Classen J, Gerloff C, et al. Depression of motor cortex excitability by low-frequency transcranial magnetic stimulation. Neurology 1997; 48(5): 1398-1403. Go to original source... Go to PubMed...
  24. Daskalakis ZJ, Möller BM, Christensen BK, et al. The effects of repetitive transcranial magnetic stimulation on cortical inhibition in healthy human subjects. Exp Brain Res 2006; 174(3): 403-412. Go to original source... Go to PubMed...
  25. George MS, Wassermann EM, Kimbrell TA, et al. Mood improvement following daily left prefrontal repetitive transcranial magnetic stimulation in patients with depression: a placebo-controlled crossover trial. Am J Psychiatry 1997; 154(12): 1752-1756. Go to original source... Go to PubMed...
  26. Figiel GS, Epstein C, McDonald WM, et al. The use of rapid-rate transcranial magnetic stimulation (rTMS) in refractory depressed patients. J Neuropsych Clin N 1998; 10(1): 20-25. Go to original source... Go to PubMed...
  27. Loo C, Mitchell P, Sachdev P, et al. Double-blind controlled investigation of transcranial magnetic stimulation for the treatment of resistant major depression. Am J Psychiatry 1999; 156(6): 946-948. Go to original source... Go to PubMed...
  28. Berman RM, Narasimhan M, Sanacora G, et al. A randomized clinical trial of repetitive transcranial magnetic stimulation in the treatment of major depression. Biol Psychiatry 2000; 47(4): 332-337. Go to original source... Go to PubMed...
  29. Avery DH, Holtzheimer PE 3rd, Fawaz W, et al. A controlled study of repetitive transcranial magnetic stimulation in medication-resistant major depression. Biol Psychiatry 2006; 59(2): 187-194. Go to original source... Go to PubMed...
  30. McNamara B, Ray JL, Arthurs OJ, Boniface S. Transcranial magnetic stimulation for depression and other psychiatric disorders. Psychol Med 2001; 31(7): 1141-1146. Go to original source... Go to PubMed...
  31. Holtzheimer PE 3rd, Russo J, Avery DH. A meta-analysis of repetitive transcranial magnetic stimulation in the treatment of depression. Psychopharmacology Bull 2001; 35(4): 149-169.
  32. Kozel FA, George MS. Meta-analysis of left prefrontal repetitive transcranial magnetic stimulation (rTMS) to treat depression. Journal of Psychiatric Practice 2002; 8(5): 270-275. Go to original source... Go to PubMed...
  33. Martin JLR, Barbanoj MJ, Schlaepfer TE, et al. Repetitive transcranial magnetic stimulation for the treatment of depression: systematic review and metaanalysis. Brit J Psychiatry 2003; 182(6): 480-491. Go to original source... Go to PubMed...
  34. Couturier JL. Efficacy of rapid-rate repetitive transcranial magnetic stimulation in the treatment of depression: a systematic review and meta-analysis. J Psychiatr Neurosci 2005; 30(2): 83-90.
  35. Gross M, Nakamura L, Pascual-Leone A, et al. Has repetitive transcranial magnetic stimulation (rTMS) treatment for depression improved? A systematic review and meta-analysis comparing the recent vs earlier rTMS studies. Acta Psychiatr Scand 2007; 116(3): 165-173. Go to original source... Go to PubMed...
  36. Schutter DJLG. Antidepressant efficacy of high-frequency transcranial magnetic stimulation over the left dorsolateral prefrontal cortex in double-blind sham-controlled designs: a meta-analysis. Psychol Med 2009; 39(1): 65-75. Go to original source... Go to PubMed...
  37. Lam RW, Chan P, Wilkins-Ho M, Yatham LN. Repetitive transcranial magnetic stimulation for treatment-resistant depression: a systematic review and metaanalysis. Can J Psychiatry 2008; 53(9): 621-631. Go to original source... Go to PubMed...
  38. Lisanby SH, Husain MM, Rosenquist PB, et al. Daily left prefrontal repetitive transcranial magnetic stimulation in the acute treatment of major depression: clinical predictors of outcome in a multisite, randomized controlled clinical trial. Neuropsychopharmacol 2009; 34(2): 522-534. Go to original source... Go to PubMed...
  39. Fregni F, Marcolin MA, Myczkowski M, et al. Predictors of antidepressant response in clinical trials of transcranial magnetic stimulation. Int J Neuropsychopharmacol 2006; 9(6): 641-654. Go to original source... Go to PubMed...
  40. Brakemeier EL, Luborzewski A, Danker-Hopfe H, et al. Positive predictors for antidepressive response to prefrontal repetitive transcranial magnetic stimulation (rTMS). J Psychiatr Res 2007; 41(5): 395-403. Go to original source... Go to PubMed...
  41. Mosimann UP, Schmitt W, Greenberg BD. Repetitive transcranial magnetic stimulation: a putative add-on treatment for major depression in elderly patients. Psychiat Res 2004; 126(2): 123-133. Go to original source... Go to PubMed...
  42. Su TP, Huang CC, Wei IH. Add-on rTMS for medicationresistant depression: a randomized, double-blind, shamcontrolled trial in Chinese patients. J Clin Psychiatry 2005; 66(7): 930-937. Go to original source... Go to PubMed...
  43. Demirtas-Tatlidede A, Pearlman C, Stern WM, et al. An open-label, prospective study of repetitive transcranial magnetic stimulation (rTMS) in the long-term treatment of refractory depression: reproducibility and duration of the antidepressant effect in medication-free patients. J Clin Psychiatry 2008; 69(6): 930-934. Go to original source... Go to PubMed...




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