Psychiatr. praxi. 2011;12(1):9-12

Contemporary acute treatment trends of manic episode of bipolar disorder

doc.MUDr.Radovan Přikryl, Ph.D.
Psychiatrická klinika LF MU a FN Brno

Bipolar disorder is a common serious psychiatric illness involving recurrent episodes of depression and mood elevation. Although the

last decade has seen important advances in the pharmacotherapy of bipolar disorder, there remain substantial unmet needs in the management

of this illness. Lithium, valproate and the second generation antipsychotics (aripiprazole, quetiapine, olanzapine, risperidone

or ziprasidone) represent current emphasis of acute pharmacological treatment of manic episode. The acute treatment of manic episode

of bipolar disorder should be choosen according to contemporary guidelines with regard to subjective tolerability and adverse event

profile of specific drug.

Keywords: acute, antipsychotics, bipolar, disorder, episode, lithium, mania, treatment, valproate

Published: January 7, 2011  Show citation

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Přikryl R. Contemporary acute treatment trends of manic episode of bipolar disorder. Psychiatr. praxi. 2011;12(1):9-12.
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    References

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    28. Keck P, Versiani M, Potkin S, et al. Ziprasidone in the treatment of acute bipolar mania: a 3-week, placebo controlled, double-blind, randomized trial. Am J Psychiatry 2003; 160: 741-748. Go to original source... Go to PubMed...
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    31. Currier G, Chou J, Feifel D, et al. Acute treatment of psychotic agitation: a randomized comparison of oral treatment with risperidone and lorazepam versus intramuscular treatment with haloperidol and lorazepam. J Clin Psychiatry 2004; 65: 386-394. Go to original source... Go to PubMed...
    32. Meehan K, Zhang F, David S, et al. A double-blind, randomized comparison of the efficacy and safety of intramuscular injections of olanzapine, lorazepam, or placebo in treating acutely agitated patients diagnosed with bipolar mania. J Clin Psychopharmacol 2001; 21: 389-397. Go to original source... Go to PubMed...
    33. Battaglia J, Lindborg S, Alaka K, et al. Calming versus sedative effects of intramuscular olanzapine in agitated patients. Am J Emerg Med 2003; 21: 192-198. Go to original source... Go to PubMed...
    34. Ganesan S, Levy M, Bilsker D. Effectiveness of quetiapine treatment of aggressive psychosis in the emergency psychiatric setting: a naturalistic pilot study. New Research Abstracts, Annual Meeting of the American Psychiatric Association. Washington, D.C.: American Psychiatric Association, 2003 [Abstract NR412].
    35. Lesem M, Zajecka J, Swift R, et al. Intramuscular ziprasidone, 2 mg versus 10 mg, in the short-term management of agitated psychotic patients. J Clin Psychiatry 2001; 62: 12-18. Go to original source... Go to PubMed...
    36. Daniel D, Potkin S, Reeves K, et al. Intramuscular (IM) ziprasidone 20 mg is effective in reducing acute agitation associated with psychosis: a double-blind, randomized trial. Psychopharmacology (Berl) 2001; 155: 128-134. Go to original source... Go to PubMed...
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    52. Látalová K, Praško J. Komorbidita bipolární afektivní poruchy s jinými psychickými poruchami. Čes. a Slov. Psychiat. 2009; 105(5): 218-223.
    53. Smith LA, Cornelius V, Warnock A, et al. Pharmacological interventions for acute bipolar mania: a systematic review of randomized placebo controlled trials. Bipolar Disord 2007; 9: 551-560. Go to original source... Go to PubMed...
    54. Scherk H, Pajonk FG, Leucht S. Second-generation antipsychotic agents in the treatment of acute mania: a systematic review and meta-analysis of randomized controlled trials. Arch Gen Psychiatry 2007; 64: 442-455. Go to original source... Go to PubMed...
    55. Kusumakar V, Yatham L, Haslam D, et al. Treatment of mania, mixed state, and rapid cycling. Can J Psychiatry 1997; 42(Suppl. 2): 79S-86S. Go to PubMed...
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    82. Meehan K, Zhang F, David S, et al. A double-blind, randomized comparison of the efficacy and safety of intramuscular injections of olanzapine, lorazepam, or placebo in treating acutely agitated patients diagnosed with bipolar mania. J Clin Psychopharmacol 2001; 21: 389-397. Go to original source... Go to PubMed...
    83. Battaglia J, Lindborg S, Alaka K, et al. Calming versus sedative effects of intramuscular olanzapine in agitated patients. Am J Emerg Med 2003; 21: 192-198. Go to original source... Go to PubMed...
    84. Ganesan S, Levy M, Bilsker D. Effectiveness of quetiapine treatment of aggressive psychosis in the emergency psychiatric setting: a naturalistic pilot study. New Research Abstracts, Annual Meeting of the American Psychiatric Association. Washington, D.C.: American Psychiatric Association, 2003 [Abstract NR412].
    85. Lesem M, Zajecka J, Swift R, et al. Intramuscular ziprasidone, 2 mg versus 10 mg, in the short-term management of agitated psychotic patients. J Clin Psychiatry 2001; 62: 12-18. Go to original source... Go to PubMed...
    86. Daniel D, Potkin S, Reeves K, et al. Intramuscular (IM) ziprasidone 20 mg is effective in reducing acute agitation associated with psychosis: a double-blind, randomized trial. Psychopharmacology (Berl) 2001; 155: 128-134. Go to original source... Go to PubMed...
    87. Bieniek S, Ownby R, Penalver A, Dominguez R. A doubleblind study of lorazepam versus the combination of haloperidol and lorazepam in managing agitation. Pharmacotherapy 1998; 18: 57-62. Go to original source... Go to PubMed...
    88. Chouinard G, Annable L, Turnier L, et al. A double-blind randomized clinical trial of rapid tranquilization with I.M. clonazepam and I.M. haloperidol in agitated psychotic patients with manic symptoms. Can J Psychiatry 1993; 38(Suppl. 4): 114-S121.
    89. Yildiz A, Sachs G, Turgay A. Pharmacological management of agitation in emergency settings. Emerg Med J 2003; 20: 339-346. Go to original source... Go to PubMed...
    90. Yatham LN, Kennedy SH, Schaffer A, et al. Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines for the management of patients with bipolar disorder: update 2009. Bipolar Disord 2009; 11: 225-255. Go to original source... Go to PubMed...
    91. Kay, SR, Fiszbein A, Opler LA. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull. 1987; 13: 261-276. Go to original source... Go to PubMed...
    92. Zimbroff DL, Marcus RN, Manos G, et al. Management of acute agitation in patiens with bipolar disorder: efficacy and safety of intramuscular aripiprazole. J Clin Psychopharmacol 2007; 27: 171-176. Go to original source... Go to PubMed...
    93. Centorrino F, Meyers AL, Ahl J, et al. An observational study of the effectiveness and safety of intramuscular olanzapine in the treatment of acute agitation in patients with bipolar mania or schizophrenia/schizoaffective disorder. Hum Psychopharmacol 2007; 22: 455-462. Go to original source... Go to PubMed...
    94. Scherk H, Pajonk FG, Leucht S. Second-generation antipsychotic agents in the treatment of acute mania: a systematic review and meta-analysis of randomized controlled trials. Arch Gen Psychiatry 2007; 64: 442-455. Go to original source... Go to PubMed...
    95. Sachs GS, Gaulin BD, Gutierrez-Esteinou R, et al. Antimanic response to aripiprazole in bipolar I disorder patients is independent of the agitation level at baseline. J Clin Psychiatry 2007; 68: 1377-1383. Go to original source... Go to PubMed...
    96. Vieta E, T'joen C, McQuade RD, et al. Adjunctive aripiprazole in bipolar mania partially non-responsive to valproate/lithium: a placebo-controlled study (CN138-134). American Journal of Psychiatry: Published online 2008 April 1; doi: 10.1176/appi.ajp.2008.07101560. Go to original source... Go to PubMed...
    97. Reischies F, Hartikainen J, Berghofer A. Initial triple therapy of acute mania, adding lithium and valproate to neuroleptics. Pharmacopsychiatry 2002; 35: 244-246. Go to original source... Go to PubMed...
    98. Reischies F, Hartikainen J, Berghofer A. Initial lithium and valproate combination therapy in acute mania. Neuropsychobiology 2002; 46(Suppl. 1): 22-27. Go to original source... Go to PubMed...
    99. Sharma V, Persad E, Mazmanian D, Karunaratne K. Treatment of rapid cycling bipolar disorder with combination therapy of valproate and lithium. Can J Psychiatry 1993; 38: 137-139. Go to original source... Go to PubMed...
    100. Granneman G, Schneck D, Cavanaugh J, Witt G. Pharmacokinetic interactions and side effects resulting from concomitant administration of lithium and divalproex sodium. J Clin Psychiatry 1996; 57: 204-206.

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