Psychiatr. praxi. 2020;21(1):13-15 | DOI: 10.36290/psy.2020.002

Cognitive superagers

MUDr. Miloslav Kopeček, Ph.D.1,2, Mgr. Zuzana Frydrychová1, Mgr. Radek Heissler1, PhDr. Hana Georgi, Ph.D.3
1 Národní ústav duševního zdraví, Klecany,
2 3. lékařská fakulta, Psychiatrická klinika UK, Praha
3 Neurotrend, z. s

People aged 80 and older are called superagers if they have the episodic memory of an average sexagenarian and performing at or above 1 SD average performance for age and education on non-memory measures according to published norms. It is a captivating construct from the scientific point of view, that is a counterpart of age-related cognitive decline. The estimation of the prevalence of this phenomenon is 12 % between cognitively healthy older adults in the Czech Republic. Prevalence of amyloid β+ and APOE ε4 is equivalent between SA and non-SA, however SA have larger grey matter volume especially in hippocampus. Grey matter volume is associated with white matter (WM) integrity through vascular health status. Intervention targeted to vascular healthy status or to inflammation in WM may help to decrease the prevalence of cognitive impairment and increase the prevalence of superagers.

Keywords: aging, cognition, health, memory, superaging.

Published: May 15, 2020  Show citation

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Kopeček M, Frydrychová Z, Heissler R, Georgi H. Cognitive superagers. Psychiatr. praxi. 2020;21(1):13-15. doi: 10.36290/psy.2020.002.
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    References

    1. Nikolai T, Štěpánková H, Vyhnálek M, Kopeček M. Neuropsychologická diagnostika kognitivního deficitu ve stáří. Československá psychologie. 2016; 60 (5): 525-541.
    2. Štěpánková H, Bezdíček O, Nikolai T, Horáková K, Lukavský J, Kopeček M. Zpráva o projektu Národní normativní studie kognitivních determinant zdravého stárnutí. E‑psychologie 2015; 9: 43-64.
    3. Cabeza R, Albert M, Belleville S, Craik FIM, Duarte A, Grady CL, et al. Maintenance, reserve and compensation: the cognitive neuroscience of healthy ageing. Nat Rev Neurosci. 2018; 19(11): 701-710. Go to original source... Go to PubMed...
    4. Nyberg L, Pudas S. Successful Memory Aging. Annu Rev Psychol. 2019; 70: 219-243. Go to original source... Go to PubMed...
    5. Gefen T, Kim G, Bolbolan K, Geoly A, Ohm D, Oboudiyat C, et al. Activated Microglia in Cortical White Matter Across Cognitive Aging Trajectories. Front Aging Neurosci. 2019; 11: 94. Go to original source... Go to PubMed...
    6. Arenaza‑Urquijo EM, Przybelski SA, Lesnick TL, Graff‑Radford J, Machulda MM, Knopman DS, et al. The metabolic brain signature of cognitive resilience in the 80+: beyond Alzheimer pathologies. Brain. 2019; 142(4): 1134-1147. Go to original source... Go to PubMed...
    7. Rogalski EJ, Gefen T, Shi J, Samimi M, Bigio E, Weintraub S, et al. Youthful memory capacity in old brains: anatomic and genetic clues from the Northwestern SuperAging Project. J Cogn Neurosci. 2013; 25(1): 29-36. Go to original source... Go to PubMed...
    8. Dang C, Harrington KD, Lim YY, Ames D, Hassenstab J, Laws SM, et al. Superior Memory Reduces 8-year Risk of Mild Cognitive Impairment and Dementia But Not Amyloid beta‑Associated Cognitive Decline in Older Adults. Arch Clin Neuropsychol. 2019; 34(5): 585-598. Go to original source... Go to PubMed...
    9. Harrison TM, Weintraub S, Mesulam MM, Rogalski E. Superior memory and higher cortical volumes in unusually successful cognitive aging. J Int Neuropsychol Soc. 2012; 18(6): 1081-1085. Go to original source... Go to PubMed...
    10. Bezdicek O, Libon DJ, Stepankova H, Panenkova E, Lukavsky J, Garrett KD, et al. Development, validity, and normative data study for the 12-word Philadelphia Verbal Learning Test [czP(r)VLT-12] among older and very old Czech adults. Clin Neuropsychol. 2014; 28(7): 1162-1181. Go to original source... Go to PubMed...
    11. Cervenkova M, Heissler R, Kopecek M. Stability of memory SuperAgers over 3 years. Psych J. 2020; 9(1): 147-149. Go to original source... Go to PubMed...
    12. Cook AH, Sridhar J, Ohm D, Rademaker A, Mesulam MM, Weintraub S, et al. Rates of Cortical Atrophy in Adults 80 Years and Older With Superior vs Average Episodic Memory. JAMA. 2017; 317(13): 1373-1375. Go to original source... Go to PubMed...
    13. Gefen T, Peterson M, Papastefan ST, Martersteck A, Whitney K, Rademaker A, et al. Morphometric and histologic substrates of cingulate integrity in elders with exceptional memory capacity. J Neurosci. 2015; 35(4): 1781-1791. Go to original source... Go to PubMed...
    14. Sun FW, Stepanovic MR, Andreano J, Barrett LF, Touroutoglou A, Dickerson Bc. Youthful Brains in Older Adults: Preserved Neuroanatomy in the Default Mode and Salience Networks Contributes to Youthful Memory in Superaging. J Neurosci. 2016; 36(37):9659-9668. Go to original source... Go to PubMed...
    15. Harrison TM, Maass A, Baker SL, Jagust WJ. Brain morphology, cognition, and beta‑amyloid in older adults with superior memory performance. Neurobiol Aging. 2018; 67: 162-170. Go to original source... Go to PubMed...
    16. Dekhtyar M, Papp KV, Buckley R, Jacobs HIL, Schultz AP, Johnson KA, et al. Neuroimaging markers associated with maintenance of optimal memory performance in late‑life. Neuropsychologia. 2017; 100: 164-170. Go to original source... Go to PubMed...
    17. Vemuri P, Lesnick TG, Knopman DS, Przybelski SA, Reid RI, Mielke MM, et al. Amyloid, Vascular, and Resilience Pathways Associated with Cognitive Aging. Ann Neurol. 2019; 86(6): 866-877.Další literatura u autoraa na www.psychiatriepropraxi.cz Go to original source... Go to PubMed...
    18. Wu YT, Fratiglioni L, Matthews FE, Lobo A, Breteler MM, Skoog I, et al. Dementia in western Europe: epidemiological evidence and implications for policy making. Lancet Neurol. 2016; 15(1): 116-124. Go to original source... Go to PubMed...
    19. Wu YT, Beiser AS, Breteler MMB, Fratiglioni L, Helmer C, Hendrie HC, et al. The changing prevalence and incidence of dementia over time - current evidence. Nat Rev Neurol. 2017; 13(6): 327-339. Go to original source... Go to PubMed...
    20. Seblova D, Brayne C, Machu V, Kuklova M, Kopecek M, Cermakova P. Changes in Cognitive Impairment in the Czech Republic. J Alzheimers, DiS. 2019; 72(3): 693-670. Go to original source... Go to PubMed...
    21. Lindquist KA, Satpute AB, Wager TD, Weber J, Barrett LF. The Brain Basis of Positive and Negative Affect: Evidence from a Meta‑Analysis of the Human Neuroimaging Literature. Cereb Cortex. 2016; 26(5): 1910-1922. Go to original source... Go to PubMed...
    22. Cook Maher A, Kielb S, Loyer E, Connelley M, Rademaker A, Mesulam M‑M, et al. Psychological well‑being in elderly adults with extraordinary episodic memory. PLoS ONE. 2017; 12(10): e0186413. Go to original source... Go to PubMed...
    23. Risk reduction of cognitive decline and dementia: WHO guidelines. Geneva: World Health Organization; 2019. Dostupný na WWW https://www.who.int/mental_health/neurology/dementia/guidelines_risk_reduction/en/
    24. Gottesman RF, Albert MS, Alonso A, et al. Associations Between Midlife Vascular Risk Factors and 25-Year Incident Dementia in the Atherosclerosis Risk in Communities (ARIC) Cohort. JAMA Neurol. 2017; 74(10): 1246-1254. Go to original source... Go to PubMed...
    25. Wang WY, Tan MS, Yu JT, Tan L. Role of pro‑inflammatory cytokines released from microglia in Alzheimer's disease. Ann Transl Med. 2015;3(10): 136. Go to PubMed...
    26. Kalkman HO, Feuerbach D. Antidepressant therapies inhibit inflammation and microglial M1-polarization. Pharmacol Ther. 2016; 163: 82-93. Go to original source... Go to PubMed...
    27. Yu XB, Zhang HN, Dai Y, Zhou ZY, Xu RA, Hu LF et al. Simvastatin prevents and ameliorates depressive behaviors via neuroinflammatory regulation in mice. J Affect Disord. 2019; 245: 939-949. Go to original source... Go to PubMed...
    28. Liu H, Yang J, Wang K, Niu T, Huang D. Moderate- and Low‑Dose of Atorvastatin Alleviate Cognition Impairment Induced by High‑Fat Diet via Sirt1 Activation. Neurochem Res. 2019; 44(5): 1065-1078. Go to original source... Go to PubMed...
    29. Yi HJ, Lee JE, Lee DH, Kim YI, Cho CB, Kim IS et al. The role of NLRP3 in traumatic brain injury and its regulation by pioglitazone. J Neurosurg. 2019; 27:1-9.
    30. Beheshti F, Hosseini M, Hashemzehi M, Soukhtanloo M, Khazaei M, Shafei MN. The effects of PPAR‑γ agonist pioglitazone on hippocampal cytokines, brain‑derived neurotrophic factor, memory impairment, and oxidative stress status in lipopolysaccharide‑treated rats. Iran J Basic Med Sci. 2019; 22(8): 940-948.
    31. Li J, Shen X. Effect of rosiglitazone on inflammatory cytokines and oxidative stress after intensive insulin therapy in patients with newly diagnosed type 2 diabetes. Diabetol Metab Syndr. 2019; 11: 35. Go to original source... Go to PubMed...
    32. Rivera AD, Butt AM. Astrocytes are direct cellular targets of lithium treatment: novel roles for lysyl oxidase and peroxisome‑proliferator activated receptor‑γ as astroglial targets of lithium. Transl Psychiatry. 2019; 9(1): 211. Go to original source... Go to PubMed...
    33. Bi J, Chen C, Sun P, Tan H, Feng F, Shen J. Neuroprotective effect of omega-3 fatty acids on spinal cord injury induced rats. Brain Behav. 2019; 9(8): e01339. Go to original source... Go to PubMed...
    34. Wang Q, Zhu Z, Liu Y, Tu X, He J. Relationship between serum vitamin D levels and inflammatory markers in acute stroke patients. Brain Behav. 2018; 8(2): e00885. Go to original source... Go to PubMed...
    35. Harris SA, Harris EA. Molecular Mechanisms for Herpes Simplex Virus Type 1 Pathogenesis in Alzheimer's Disease. Front Aging Neurosci. 2018; 10: 48. Go to original source... Go to PubMed...
    36. Dominy SS, Lynch C, Ermini F, Benedyk M, Marczyk A, Konradi A et al. Porphyromonas gingivalis in Alzheimer's disease brains: Evidence for disease causation and treatment with small‑molecule inhibitors. Sci Adv. 2019; 5(1): eaau3333. Go to original source...

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