Slovo úvodem

MUDr. Radkin Honzák, CSc.

Psychiatr. praxi. 2016;17(1):3  

Trazodone in the treatment of behavioral and psychological symptoms of dementia

doc. MUDr. Roman Jirák, CSc.

Psychiatr. praxi. 2016;17(1):6-8 | DOI: 10.36290/psy.2016.002  

The effect of trazodone on behavioral and psychological symptoms of dementia was examined in a postauthorisation noninterventional study in patients suffering from different types of demenia. Trazodone controlled-release (Trittico AC) proved to be an effective treatment with minimal side effects. Sleep disorders, depression, anxiety and agitation were affected to the highest degree. Trazodone represents a more safe alternative to the commonly used antipsychotic drugs.

Therapeutic drug monitoring in psychiatry - possibilities and use in practice

MUDr. Petr Šilhán, MUDr. Ivana Kacířová, Ph.D., MUDr. Martin Hýža, Mgr. Romana Uřinovská, Ph.D., prof. MUDr. Eva Češková, CSc., doc. MUDr. Milan Grundmann, CSc.

Psychiatr. praxi. 2016;17(1):10-14 | DOI: 10.36290/psy.2016.003  

A treatment individualisation is one of basic ways to patient care improvement. A therapeutic drug monitoring (TDM) is its main tool, which uses drug concentration assessment in blood in order to achieve the maximum effect with the minimum risk of toxicity. Actually, it is to be expected that individual pharmacokinetic differences will lead to 20fold differences in steady state drug concentration at the very same doses of psychopharmacs. TDM is nowadays a routine method only in the treatment with typical mood stabilizers. Nevertheless, according to international guidelines most antipsychotics, antidepressants, but also a number of drugs for addiction...

Results of therapeutically castration by paraphiliac sexual offenders

doc. MUDr. Jaroslav Zvěřina, CSc., prof. PhDr. Petr Weiss, Ph.D., DSc., MUDr. Martin Hollý, MBA

Psychiatr. praxi. 2016;17(1):15-17 | DOI: 10.36290/psy.2016.004  

Overview of results of therapeutically castration by 50 paraphiliac sexual offenders. This surgical procedure substantially reduced specific recidivism. 2 (4%) respondents only committed other sexual delict after therapeutically castration. There are not substantially reduction in nonsexual delinquency. Somatic and psychic negative changes after castration were not frequent. This surgical procedure substantially reduced sexual activity of respondents. Majority of respondents judged the surgery as positive. A small part of respondents have some hesitation about voluntariness their consent to the surgery.

Telemedicine in psychiatry

MUDr. Miroslava Žáčková, MUDr. Hana Valentová, MUDr. Sylva Racková Ph.D., MUDr. Luboš Janů Ph.D.

Psychiatr. praxi. 2016;17(1):18-21 | DOI: 10.36290/psy.2016.005  

There is increased interest in telemedicine. Telepsychiatry is not the first specialty. The use of telecommunications technologies to provide medical services, could be used because of various reasons. The use of telemedicine is based on the aim to improve acces to psychiatric care, cost effectivity and decrease stigma of psychiatry for public people. Cons an pros are discussed in the article. There is need for further studies in different contries to estabilish regulations and standards for the use. Subjective acceptation is mainly based on the cooperation between health specialists, clients and regulative authorities. Improving health care as the...

Self-harm during childhood and adolescence

Mgr. MUDr. Eva Rozsívalová

Psychiatr. praxi. 2016;17(1):22-24  

Deliberate self-harm and self-injury is an inappropriate and harmful way of coping with problems. This is a behavioral manifestation observed during childhood and adolescence. This involves superficial self-cutting, self-immolation, overdosing with medicines or other chemical substances, self-beating, self-strangulation, wound self-laceration, hair removal and others. Adolescents want to hurt themselves and stay alive. They hide the self-harm consequences, the process itself is more important than the result during which he experiences craving, arousal increase, its depletion and alleviation associated with the need of recurrence. The therapy makes...

Use of atomoxetine in the treatment of adult ADHD - case study

MUDr. Bc. Daniela Zmeškalová, prof. MUDr. Ján Praško, CSc.

Psychiatr. praxi. 2016;17(1):25-27 | DOI: 10.36290/psy.2016.007  

The case study describes a young adult woman coming to a psychiatric clinic primarily for problems with attention deficit. The patient is diagnosed with ADHD and started on non-stimulant medication atomoxetine, causing improvement in attention, impulsivity and hyperactivity leading to improvement in academic functioning and better time management.

Epilepsy and excoriation (Skin-Picking) disorder

MUDr. Jan Hubeňák, Ph.D.

Psychiatr. praxi. 2016;17(1):28-30 | DOI: 10.36290/psy.2016.008  

Excoriation (Skin-Picking) disorder is a new diagnostic category presented in DSM-5 and is expected to occur in ICD-11. It is supposed to be linked to a dysfunction in frontal lobe cortex. Glutamatergic transmission may be impaired as well. Case of herein presented patient suffering from comorbidity of excoriation disorder, epilepsy and adjustment disorder with prolonged depressive reaction demonstrates still limited therapeutic knowledge.

Vortioxetine: a review of new antidepressant

prof. MUDr. Pavel Mohr, Ph.D., MUDr. Tomáš Melicher, MUDr. Pavel Knytl

Psychiatr. praxi. 2016;17(1):31-32 | DOI: 10.36290/psy.2016.009  

Vortioxetine is a novel antidepressant with multimodal mechanism of action, acting as 5-HT3A, 5-HT7, and 5-HT1D receptor antagonist, 5-HT1A agonist, 5-HT1B partial agonist, and serotonin transporter inhibitor. Antidepressant efficacy of vortioxetine 10–20 mg daily has been shown in the total of 13 acute short-term and 1 relapse-prevention controlled trials. Moreover, in 3 placebo-controlled trials vortioxetine improved cognitive functions, independent of antidepressive effects. Vortioxetine was well-tolerated, with low incidence of sexual dysfunction. Most frequently reported side effects were transient and dose-dependent nausea and vomiting....