Psychiatr. pro Praxi, 2006; 2: 66-69

BEHAVIORAL DISTURBANCES IN DEMENTIA

MUDr. Martin Brunovský Ph.D
Psychiatrické centrum Praha, 3. LF UK, Praha

The symptoms of behavioral disturbance represent common and serious hallmarks in patients with dementia. A wide variety of pharmacological agents are used in the management of behavioral symptoms of dementia, however with controversial effectivity. The article brings an overview of frequently mentioned behavioral diturbances in dementia (agitation, aggression, affective disorders, sleep impairment etc.) and current evidence-based approach to their treatment.

Keywords: ey words: dementia, Alzheimer disease, behavioral disturbances, cholinesterase inhibitors, 1st generation of antipsychotics, 2nd gene­ration of antipsychotics.

Published: April 1, 2006  Show citation

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Brunovský M. BEHAVIORAL DISTURBANCES IN DEMENTIA. Psychiatr. praxi. 2006;7(2):66-69.
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    References

    1. Anand R, Messina J, Hartman R, et al. Maximising functional ability: new data with cholinesterase inhibitors. Int J Psychogeriatr 1999; 11(suppl. 1): 86.
    2. Ancoli-Israel S, Klauber MR, Gillin JC, Campbell SS, Hofstetter CR. Sleep in non-institutionalized Alzheimer's disease patients. Aging Clin. Exp. Res. 1994; 6: 451-458. Go to original source... Go to PubMed...
    3. APA Annual Meeting 2005: Abstract 57A. Presented May 25, 2005. (http://www.medscape.com/viewarticle/505789).
    4. Baker R, Holloway J, Holtkamp CC, et al. Effects of multi-sensory stimulation for people with dementia. J Adv Nurs 2003; 43: 465-77. Go to original source... Go to PubMed...
    5. Brunovský M, Červená K, Matoušek M. Poruchy spánku u demencí. Neurologie pro praxi 2002; 3: 134-137.
    6. Camberg L, Woods P, Ooi WL, et al. Evaluation of simulated presence: a personalized approach to enhance well-being in persons with Alzheimer's disease. J Am Geriatr Soc 1999; 47: 446-52. Go to original source... Go to PubMed...
    7. Cohen-Mansfield J, Billig N. Agitated behaviors in the elderly. I. A conceptual review. Journal of the American Geriatrics Society 1986; 34: 711-721. Go to original source... Go to PubMed...
    8. Cohen-Mansfield J, Werner P. Management of verbally disruptive behaviors in nursing home residents. J Gerontology A Biol Sci Med Sci 1997; 52A: 369-77. Go to original source... Go to PubMed...
    9. Cohen-Mansfield J. Nonpharmacologic interventions for inappropriate behaviors in dementia: a review, summary, critique. Am J Geriatric Psychiatry 2001; 9: 361-81. Go to original source...
    10. Český statistický úřad, 2005. (http://www.czso.cz/csu/edicniplan.nsf/p/4020-03).
    11. Diagnostic and Statistical Manual of Mental Disorders (DSM-IV). American Psychiatric Association, Washington, 1994.
    12. Finkel SI, Costa e Silva J, Cohen G, et al. Behavioral and psychological signs and symptoms of dementia: a consensus statement on current knowledge and implications for research and treatment. Int Psychogeriatr 1996; 8: 497-512. Go to original source... Go to PubMed...
    13. Herrmann N, Mamdani M, Lanctot KL. Atypical antipsychotics and risk of cerebrovascular accidents. American Journal of Psychiatry 2004; 161: 1113-1115. Go to original source... Go to PubMed...
    14. Lonergan E, Luxenberg J, Colford J. Haloperidol for agitation in dementia. Cochrane Database Syst Rev 2002: 2: CD002852. Go to original source...
    15. Lyketsos CG, Polez O, Jones B, Fitzpatrick AL, Breitner J, DeKosky S. Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment: results from the Cardiovascular Health Study. JAMA 2002; 288: 1475-1483. Go to original source... Go to PubMed...
    16. Mintzer JE. Managing behavioral dyscontrol related to dementia. Prim Care Companion J Clin Psychiatry 2003; 5(Suppl 6): 14-21.
    17. Stong C. Antipsychotic use in enderly patients with dementia prompts new FDA warning. Neopsychiatry reviews 2005 vol. 6, no 5 (June 2000) (www.neuropsychiatryreviews.com).
    18. Pollock BG, Pulsant BH, Rosen J, et al.: Comparison of citalopram, perphenazine, and placebo for the acute treatment of psychosis and behavioral disturbances in hospitalized, demented patiens. Am J Psychiatry 2002; 159: 460-465. Go to original source... Go to PubMed...
    19. Rosler M. The efficacy of cholinesterase inhibitors in treating the behavioural symptoms of dementia. Int J Clin Pract 2002; 127: 20-36.
    20. Sink KM, Covinsky KE, Newcomer R, Yaffe K. Ethnic differences in the prevalence and pattern of dementia-related behaviors. J Am Geriatr Soc 2004; 52: 1277-1283. Go to original source... Go to PubMed...
    21. Sink KM, Holden KF, Yaffe K. Pharmacological treatment of neuropsychiatric symptoms of dementia. A review of the evidence. JAMA 2005; 293: 596-608. Go to original source... Go to PubMed...
    22. Teri L, Hughes JP, Larson EB. Cognitive deterioration in Alzheimer's disease: behavioral and health factors. J Gerontol 1990; 45: 58-63. Go to original source... Go to PubMed...
    23. Trinh NH, Hoblyn J, Mohanty S, Yaffe K. Efficacy of cholinesterase inhibitors in the treatment of neuropsychiatric symptoms and functional impairment in Alzheimer disease: a meta-analysis. JAMA 2003; 289: 210-216. Go to original source... Go to PubMed...
    24. USFDA Web site: www.fda.gov/cder/drug/advisory/antipsychotics.htm.
    25. Wang PS, Schneeweiss S, Avorn J, Fischer MA, Mogun H, Solomon DH, Brookhart MA. Risk of death in elderly users of conventional vs. atypical antipsychotic medications. N Engl J Med 2005; 353(22): 2335-2341. Go to original source... Go to PubMed...

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