Psychiatr. pro Praxi, 2006; 3: 146-148

Trazodon v léčbě deprese s úzkostí a nespavosti

prof. MUDr. Eva Češková CSc
Psychiatrická klinika LF MU a FN Brno

V současné době máme k dispozici specifická antidepresiva, selektivně ovlivňující dostupnost základních monoaminových neurotransmiterů spojovaných s depresí. Důraz na znalost mechanizmu účinku a zavedení nových galenických forem obnovily zájem o některé starší preparáty včetně trazodonu. Trazodon je specifické serotonergní antidepresivum charakterizované mírnou inhibicí zpětného vychytávání serotononinu a silnou blokádou serotoninových receptorů typu 5-HT 2A. Kromě antidepresivního působení má anxiolytické vlastnosti a pozitivně ovlivňuje poruchy spánku včetně úpravy spánkové architektury. Výhodné je, že nepůsobí sexuální dysfunkce. Tyto jeho vlastnosti lze využít při volbě antidepresiva dle převažujících příznaků. V ČR je dostupný pouze trazodon ve formě s pomalým uvolňováním (Trittico AC), u kterého předpokládáme oproti klasickému trazodonu nižší výskyt vedlejších účinků a lepší komplianci.

Keywords: specifická antidepresiva, serotonin, trazodon, anxieta, insomnie

Published: July 1, 2006  Show citation

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Češková E. Trazodon v léčbě deprese s úzkostí a nespavosti. Psychiatr. praxi. 2006;7(3):146-148.
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