Psychiatr. pro Praxi, 2007; 8(6): 247-249

How to predict the response to antidepressants?

MUDr. Miloslav Kopeček Ph.D1,2
1 Psychiatrické centrum Praha, 3. LF UK, Praha
2 3. LF UK, Praha

Evidence based medicine confirmed that antidepressants are effective in the treatment of depression, but until today it is not clear what antidepressant would be best for which patient. Results from EEG studies indicate that after one week of antidepressant treatment we can correctly predict 8 out of 10 patients will not responsed to treatment with a given antidepressant if we continue with it further 3–7 weeks. EEG could help to chooise right antidepressant in similar way as cultivation helps to choose right antibiotic.

Keywords: antidepressants, prediction, electroencephalography, depressive disorder

Published: January 15, 2008  Show citation

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Kopeček M. How to predict the response to antidepressants? Psychiatr. praxi. 2007;8(6):247-249.
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    References

    1. Bares M, Brunovsky M, Kopecek M, Stopkova P, Novak T, Kozeny J, Hoschl C. Changes in QEEG prefrontal cordance as a predictor of response to antidepressants in patients with treatment resistant depressive disorder: A pilot study. J Psychiatr Res 2007; 41: 319-325. Go to original source... Go to PubMed...
    2. Bareš M, Brunovský M, Kopeček M, Stopková P, Novák T, Kožený J, Čermák J, Šoš P, Höschl C. EEG v predikci odpovědi na antidepresiva u pacientů s depresivní poruchou: Přehled a rozšířená pilotní data. Psychiatrie 2006; 10: 205-210.
    3. Bareš M, Praško J. Depresivní porucha. In: Postupy v léčbě psychických poruch, edited by Seifertová D, Praško J and Höschl C. Praha: Academia medica Pragensis, 2004.
    4. Burke WJ, Gergel I, Bose A. Fixed-dose trial of the single isomer SSRI escitalopram in depressed outpatients. J Clin Psychiatry 2002; 63: 331-336. Go to original source... Go to PubMed...
    5. Češková E. Volba antidepresiva. Remedia 2002; 13: 426-436.
    6. Dodd S, Berk M. Predictors of antidepressant response: a selective review. International Journal of Psychiatry in Clinical Practice 2004; 8: 91-100. Go to original source... Go to PubMed...
    7. Hosák L. Klinický přínos farmakogenetiky v psychiatrii. Psychiat. pro Praxi 2006; 7(4): 168-170.
    8. Kim H, Lim SW, Kim S, Kim JW, Chang YH, Carroll BJ, and Kim DK. Monoamine transporter gene polymorphisms and antidepressant response in koreans with late-life depression. JAMA 2006; 296: 1609-1618. Go to original source... Go to PubMed...
    9. Kopeček M, Bareš M, Brunovský M, Novák T, Stopková P, Kožený J. EEG kordance jako prediktor antidepresivní odpovědi - souhrn 3 studií. Psychiatrie 2006;10: 61-62.
    10. Kopeček M, Bareš M, Brunovský M, Stopková P. EEG kordance jako prediktor antidepresivní odpovědi. Psychiatrie 2007; 11: 78-81.
    11. Kopeček M, Bareš M, Horáček J. Jedna nebo více velkých depresivních poruch? Individualizovaná PET analýza u pacientů s depresivní poruchou. Psychiatrie 2007; 11(Suppl 3): 71-78.
    12. Mišurec J, Náhunek K, Švestka J, Češková E. EEG changes after single dose maprotiline and their correlation with the therapeutic effect. Activ. Nerv. Supl.1982; 24: 288-290.
    13. Kornstein SG, Schatzberg AF, Thase ME, Yonkers KA, McCullough JP, Keitner GI, Gelenberg AJ, Davis SM, Harrison WM, Keller MB. Gender differences in treatment response to sertraline versus imipramine in chronic depression. Am J Psychiatry 2000; 157: 1445-1452. Go to original source... Go to PubMed...
    14. Papakostas GI, Thase ME, Fava M, Craig Nelson J, Shelton RC. Are antidepressant drugs that combine serotonergic and noradrenergic mechanisms of action more effective than the selective serotonin reuptake inhibitors in treating major depressive disorder? A meta-analysis of studies of newer agents. Biol Psychiatry, 2007. e-pub. Go to original source...
    15. Perlis RH. Pharmacogenetic studies of antidepressant response: how far from the clinic? Psychiatr Clin North Am 2007; 30: 125-138. Go to original source... Go to PubMed...
    16. Perlis RH, Iosifescu DV, Renshaw PF. Biological predictors of treatment response in affective illness. Psychiatr Clin North Am 200326: 323-344, vii. Go to original source...
    17. Pinto-Meza A, Usall J, Serrano-Blanco A, Suarez D, Haro JM. Gender differences in response to antidepressant treatment prescribed in primary care. Does menopause make a difference? J Affect Disord 2006; 93: 53-60. Go to original source... Go to PubMed...
    18. Posternak MA, Zimmerman M. Is there a delay in the antidepressant effect? A meta-analysis. J Clin Psychiatry 2005; 66: 148-158. Go to original source... Go to PubMed...
    19. Raboch J, Anders M, Kryl M. Depresivní poruchy u dospělých. In: Doporučené postupy psychiatrické péče II., edited by Raboch J, Anders M, Praško J and Hellerová P. Praha: Infopharm, 2006, p. 204.
    20. Rush AJ, Trivedi MH, Wisniewski SR, Nierenberg AA, Stewart JW, Warden D, Niederehe G, Thase ME, Lavori PW, Lebowitz BD, McGrath PJ, Rosenbaum JF, Sackeim HA, Kupfer DJ, Luther J, Fava M. Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report. Am J Psychiatry 2006; 163: 1905-1917. Go to original source... Go to PubMed...
    21. Trivedi MH, Kurian BT, Grannemann BD. Clinical predictors in major depressive disorder. Primary Psychiatry 2007; 14: 47-53.
    22. Wohlfarth T, Storosum JG, Elferink AJ, van Zwieten BJ, Fouwels A, van den Brink W. Response to tricyclic antidepressants: independent of gender? Am J Psychiatry 2004; 161: 370-372. Go to original source... Go to PubMed...

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