Psychiatr. pro Praxi, 2008; 9(1): 15-18 [Neurol. praxi. 2007;8(5):295-298]

Behavioral disorders in patients with Alzheimer disease

doc. MUDr. Roman Jirák CSc
Psychiatrická klinika 1. LF UK a VFN Praha

One of the three basic involvement in Alzheimer disease and other types of dementia are (besides impairment of cognitive function and activities of daily life) so called behavioral and psychological symptoms of dementia. These disorders include also involvement of emotivity (depression, anxiety, etc.) sleeping disorders and sleeping-vigilance cycle impairment and also behavioral disorders. These disorders are sometimes the most dominant and most disturbing, especially in middle and advanced stages of the disease. They may have different forms. Agitation-persistent and sometimes only slight restlessness is very frequent. Psychotic symptoms sometimes accompany behavioral disorders, e.g. delusions, hallucinations, misinterpretation. Options of agitation treatment are discussed.

Keywords: Alzheimer disease, antipsychotics, dementia, behavioral disorder, agitation

Published: February 1, 2008  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Jirák R. Behavioral disorders in patients with Alzheimer disease. Psychiatr. praxi. 2008;9(1):15-18.
Download citation

References

  1. Bayer A, Reban J (eds.): Alzheimer's disease and related dementias. Medea Press, 2004, 330 s.
  2. Brodaty H, Ames D, Snowden J et al. A randomized placebo-controlled trial of risperidone for the treatment of agression, agitation, and psychosis of dementia. J Clin Psychiatry, 2003; 64: 134-143. Go to original source... Go to PubMed...
  3. Caltagirone C, Bianchetti A, Di Luca M et al. Guidelines for the treatment of Alzheimer´s disease from the Italian Association of Psychogeriatrics. Drugs & Aging 2005; 22 Suppl. 1: 1-26. Go to original source... Go to PubMed...
  4. Jirák R, Koukolík F. Demence. Galen, Praha, 2004, 335 s.
  5. Jirák R, Borzová C, Konrád J, Franková V, Spousta S. Demence. In: Psychiatrie, doporučené postupy psychiatrické péče II, ed. Raboch J, Anders M, Praško J. Hellerová P. Infopharm, Praha, 2006, s. 22-37.
  6. Katz I, Jeste DV, Mintzer JE et al. Comparison of risperidone and placebo for psychosis and behavioral disturbances associated with dementia: a randomized, double-blind trial. J Clin Psychiatry, 1999; 60: 107-115. Go to original source... Go to PubMed...
  7. Longeran E, Luxenberg J, Colford J. Haloperidol for agitation in dementia. Cochrane Database Syst Rev. 2002; 2: CD002852. Go to original source...
  8. Meehan KM, Wang H, David SR et al. Comparison of rapidly acting intramuscular olanzapine, lorazepam, and placebo: a doubleblind, randomized study in acutely agitated patients with dementia. Neuropsychopharmacology, 2002; 26: 494-504. Go to original source... Go to PubMed...
  9. Schneider LS, Pollock VE, Lyness SA. A metaanalysis of controlled trials of neuroleptic treatment in dementia. J AM Geriatr Soc. 1990; 38: 553-563. Go to original source... Go to PubMed...
  10. Street JS, Clark WS, Gannon KS et al. Olanzapine treatment of psychotic and behavioral symptoms in patients with Alzheimer disease in nursing care facilities: A double-blind, randomized, placebo-controlled trial. Arch Gen Psychiatry, 2000; 57: 968-976. Go to original source... Go to PubMed...




Psychiatry for Practice

Madam, Sir,
please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

I declare:

  1. that I have met the above instruction
  2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited


No

Yes

If your statement is not true, please be aware
that brings the risk of danger to their health or the health of others.