Psychiatr. praxi. 2011;12(2):52-55

The antidepressive medication in the treatment of schizophrenia

MUDr.Luboš Janů, Ph.D.1, MUDr.Sylva Racková2,3
1 Fachklinik Furth im Wald
2 Univerzita Karlova v Praze, Lékařská fakulta v Plzni
3 Fakultní nemocnice v Plzni

Antidepressants are probably overused in population of schizophrenia patients. Only for some schizophrenic patients suffering from

resistent negative symptoms, serious and long-term depression are antidepressants of some benefits. The appropriate dose has key

importancy for reducing of affective symptoms during schizophrenia treatment.

Keywords: schizophrenia, depression, antidepressants, antipsychotics

Published: May 1, 2011  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Janů L, Racková S. The antidepressive medication in the treatment of schizophrenia. Psychiatr. praxi. 2011;12(2):52-55.
Download citation

References

  1. Buckley P, Miller BJ, Lehrer DS, Castle DJ. Psychiatric Comorbidities and Schizophrenia. Schizophr Bull 2009; 35(2): 383-402. Go to original source... Go to PubMed...
  2. Freudenreich O, Tranulis C, Cather C. Depressive symptoms in schizophrenia outpatients - prevalence and clinical correlates. Clin Schizophr Relat Psychoses 2008; 2: 127-135. Go to original source...
  3. Mojtabai R, Olfson M. National trends in psychotropic medication polypharmacy in office-based psychiatry. Arch Gen Psychiatry 2010; 67: 26-36. Go to original source... Go to PubMed...
  4. Janů L, Racková S. Léčba deprese pacientů se schizofrenií. Psychiat. praxi; 2008; 9(4): 161-165.
  5. Johnson DAW. Depressions in schizophrenia: Some observations on prevalence, aetiology and treatment. Acta Psychiatrica Scandinavica, 1981; 63(suppl. 291): 137-144. Go to original source... Go to PubMed...
  6. Siris SG. Depressive symptoms in the course of schizophrenia. In Depression in Schizophrenia (ed. DeLisi LE), American Psychiatric Press, 1990: 3-23.
  7. Horáček J. Prolegomena ke každé budoucí psychiatrické nozologii (jež se bude moci státi vědou). Psychiatrie 2008; 12(2): 82-87.
  8. Mulholland C, Cooper S. The symptoms of depression in schizophrenia and its management. Advan. Psychiatr. Treat, 2000; 6: 169-177. Go to original source...
  9. Knights A, Hirsch SR. Revealed' depression and drug treatment for schizophrenia. Archives of General Psychiatry 1981; 38: 806-811. Go to original source... Go to PubMed...
  10. Racková S, Janů L. Subjektivní reakce v akutní léčbě schizofrenie. Remedia 2005; 15(6): 509-513.
  11. Walker EF, Cornblatt BA, Addington J, et al. The relation of antipsychotic and antidepressant medication with baseline symptoms and symptom progression: A naturalistic study of the North American Prodrome Longitudinal Sample. Schizophr Res. 2009; 115(1): 50-57. Go to original source... Go to PubMed...
  12. Siris SG. Depression in Schizophrenia: Perspective in the Era of, ,Atypical" Antipsychotic Agents Am J Psychiatry 2000; 157: 1379-1389. Go to original source... Go to PubMed...
  13. Pogue-Geile M. Negative symptoms and depression in schizophrenia. In Depression in Schizophrenics (eds. Williams R, Dalby JT) Plenum, 1989: 121-130. Go to original source...
  14. Whitehead C, Moss S, Cardno A, Lewis G. Antidepressants for people with both schizophrenia and depression. Cochrane Database Syst Rev. 2002; (2): CD002305. Go to original source...
  15. Cooke M, Petersa E, Fannon D, et al. Insight, distress and coping styles in schizophrenia. Schizophrenia Research 2007; 94: 12-22. Go to original source... Go to PubMed...
  16. Siris SG. Assessment and treatment of depression in schizophrenia. Psychiatric Annals 1994, 24: 463-467. Go to original source...
  17. Erhart SM, Marder SR, Carpenter WT. Treatment of Schizophrenia Negative Symptoms: Future Prospects. Schizophrenia Bulletin 2006; 32(2): 234-237. Go to original source... Go to PubMed...
  18. Singh SP, Singh V, Kar N, Chan K. Efficacy of antidepressants in treating the negative symptoms of chronic schizophrenia: meta-analysis. Br J Psychiatry 2010; 197(3): 174-179. Go to original source... Go to PubMed...
  19. Silver H, Chertkow Y, Weinreb O, et al. Multifunctional pharmacotherapy: what can we learn from study of selective serotonin reuptake inhibitor augmentation of antipsychotics in negative-symptom schizophrenia? Neurotherapeutics 2009; 6(1): 86-93. Go to original source... Go to PubMed...
  20. Abbasi SH, Behpournia H, Ghoreshi A, et al. The effect of mirtazapine add on therapy to risperidone in the treatment of schizophrenia: a double-blind randomized placebo-controlled trial. Schizophr Res. 2010; 116 (2-3): 101-106. Go to original source... Go to PubMed...
  21. Terevnikov V, Stenberg JH, Joffe M, et al. More evidence on additive antipsychotic effect of adjunctive mirtazapine in schizophrenia: an extension phase of a randomized controlled trial. Hum Psychopharmacol. 2010; 25(6): 431-438. Go to original source... Go to PubMed...
  22. Iancu I, Tschernihovsky E, Bodner E, Piconne AS, Lowengrub K. Escitalopram in the treatment of negative symptoms in patients with chronic schizophrenia: a randomized double-blind placebo-controlled trial. Psychiatry Res. 2010; 179(1): 19-23. Go to original source... Go to PubMed...
  23. Berk M, Gama CS, Sundram S, et al. Mirtazapine addon therapy in the treatment of schizophrenia with atypical antipsychotics: a double-blind, randomised, placebo-controlled clinical trial. Hum Psychopharmacol. 2009; 24(3): 233-238. Go to original source... Go to PubMed...
  24. Hirsch SR, Jolley AG, Barnes TRE, et al. Dysphoric and depressive symptoms in chronic schizophrenia. Schizophrenia Research, 1989; 2: 259-264. Go to original source... Go to PubMed...
  25. Moller HJ. Antipsychotic and antidepressive effects of second generation antipsychotics. Two different pharmacological mechanism? Eur Arch Psychiatry Clin Neurosci 2005; 255: 190-201. Go to original source... Go to PubMed...
  26. Moller HJ. Drug treatment of depressive symptoms in schizophrenia. Clin Schizophr Relat Psychoses. 2007; 1: 328-340. Go to original source...
  27. Van Putten T, May PRA. Akinetic depression in schizophrenia. Archives of General Psychiatry 1978; 35: 1101-1107. Go to original source... Go to PubMed...
  28. Drake RE, Cotton PG. Depression, hopelessness and suicide in chronic schizophrenia. British Journal of Psychiatry, 1986; 148: 554-559. Go to original source... Go to PubMed...
  29. Collins A, Remington G, Coulter K, Birkett K. Insight, neurocognitive function and symptom clusters in chronic schizophrenia. Schizophrenia Research. 1997; 27(1): 37-44. Go to original source... Go to PubMed...
  30. Carrol A. Correlates of insight and insight change in schizophrenia. Schizophrenia Research 1999; 137(3): 247-253. Go to original source... Go to PubMed...
  31. Weiden P, Havens L. Psychotherapeutic management techniques in the treatment of outpatients with schizophrenia. Hosp Community Psychiatry 1994; 45(6): 549-555. Go to original source... Go to PubMed...
  32. Glazer W, Prusoff B, John K. Depression and social adjustment among chronic schizophrenic outpatients. Journal of Nervous and Mental Disease 1981; 169: 712-717. Go to original source... Go to PubMed...




Psychiatry for Practice

Madam, Sir,
please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

I declare:

  1. that I have met the above instruction
  2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited


No

Yes

If your statement is not true, please be aware
that brings the risk of danger to their health or the health of others.