Psychiatr. praxi. 2013;14(1):7-9

Genetics of anxiety disorders

prof.MUDr.Ladislav Hosák, Ph.D.^1,2, MUDr.Petr Šilhán¹, Mgr.Jiřina Hosáková³

¹ Katedra interních oborů, Ostravská univerzita v Ostravě, LF a Oddělení psychiatrické, FN Ostrava

² Psychiatrická klinika, Univerzita Karlova v Praze, LF v Hradci Králové a FN Hradec Králové

3Ústav ošetřovatelství, Slezská univerzita v Opavě, Fakulta veřejných politik v Opavě

Heritability of anxiety disorders is the least of all psychiatric diseases – only 20 to 40 %. Environmental factors, especially the psychotraumatizing

ones, are deciding. Although series of genetic association studies in anxiety disorders have already been performed, their

results are typically negative, inconsistent, or non-replicated. On the present day, practically no gene can be considered as a causative

one in the etiopathogenesis of anxiety disorders. A basically new knowledge can be attained by whole-genome association studies and

genetic analyses of endophenotypes in the future. It will be useful in our finding of modern biological therapies in anxiety disorders.

Keywords: anxiety disorders, genetics, whole-genome association studies, endophenotype

Published: December 1, 2012  Show citation