Psychiatr. praxi 2017; 18(3e): e3-e8 | DOI: 10.36290/psy.2017.037

The influence of lifestyle on epigenetic regulation: implications for psychiatric disorders

doc. MUDr. Jana Janoutová, Ph.D.1, 2, Mgr. Alice Hálová3, 4, prof. MUDr. Vladimír Janout, CSc.1, 2
1 1Ústav epidemiologie a ochrany veřejného zdraví, Lékařská fakulta, Ostravská univerzita
2 2Fakulta zdravotnických věd, Univerzita Palackého Olomouc
3 3Laboratoř neurobiologie a molekulární psychiatrie, Ústav biochemie, Přírodovědecká fakulta, Masarykova univerzita
4išné fyziologie a genetiky, AV ČR Brno 4Ústav živoč

Environmental factors and lifestyle can change human epigenetic status with methylation, acetylation DNA, histon methylation, miRNA expresionetc. Different epigenetic regulations can be associated with various diseases, such as tumors, cardiovascular, mental and neurodegenerative diseases. The aim of this contribution is to summarize the impal of lifestyle on epigenetic mechanisms that consequently can affect the pathogenesis ofmental disorders.A part of this publication includes an analysis of lifestyle risk factors, whitch can be related with Schizophrenia and Alzheimer´s disease from author ´s case control studies.

Keywords: psychiatric disorders, lifestyle, epigenetic regulation

Published: December 1, 2017  Show citation

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Janoutová J, Hálová A, Janout V. The influence of lifestyle on epigenetic regulation: implications for psychiatric disorders. Psychiatr. praxi. 2017;18(E-verze 3/17):e3-8. doi: 10.36290/psy.2017.037.
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