Psychiatr. praxi. 2020;21(2):83-88 | DOI: 10.36290/psy.2020.015

Mental health and immunity

MUDr. Miroslava Navrátilová, Ph.D.
Psychiatrická klinika Lékařské fakulty Masarykovy univerzity a Fakultní nemocnice Brno

The relationship between the mental state and the human immune system is known from clinical practice - short-term stress is a functional, physiological response that stimulates the immune system. Likewise, short-term inflammation is a natural reaction to injury or infection. Conversely, chronic stress worsens the response of the nervous, endocrine and immune systems and can lead to immunodeficiency. The review summarizes the clinical experience of an internist with a focus on clinical nutrition and intensive metabolic care in psychiatric patients and selected significant findings in the field of mental health and immunity.

Keywords: immunity, stress, inflammation, cancer, nutrition.

Published: June 29, 2020  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Navrátilová M. Mental health and immunity. Psychiatr. praxi. 2020;21(2):83-88. doi: 10.36290/psy.2020.015.
Zobrazit celý článek

Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Vivier E, Van de Pavert Serge A, Cooper Max D. The evolution of innate lymphoid cells. Nature immunology. 2016; 21(17): 7, 790-794 s. Go to original source...
    2. Baumeister D, Russell A, Pariante CM, Mondelli V. Inflammatory biomarker profiles of mental disorders and their relation to clinical, social and lifestyle factors. Soc Psychiatry Psychiatr Epidemiol 2014; 49: 841-849 Go to original source...
    3. Hořejší V. https://ceskapozice.lidovky.cz/tema/ocekavani‑spousti‑biochemicke‑deje‑jez‑ho‑mohou‑naplnit.A180919_154920_pozice‑tema_lube, http://www.amgen.com
    4. Höschl C, Horáček J. Duše jako imunomodulátor. Vnitr Lek 2016; 62(4): 36-41.
    5. Adam TC, Epel ES. Stress, Eating and the Reward System. Physiol Behav. 2007; 24(91): 449-458 Go to original source...
    6. Fortuna JL. Sweet preference, sugar addiction and the familial history of alcohol dependence: shared neural pathways and genes. J Psychoactive Drugs 2010; 42(2): 147-151. Go to original source... Go to PubMed...
    7. Björntorp P. Do stress reactions cause abdominal obesity and comorbidities? Obes Rev 2001; 2: 73-86. Go to original source... Go to PubMed...
    8. Stunkard A, Alisson K, Lundgren J. Issues for DSM‑V. Night eating syndrome. Am J Psychiatry 2008; 165(4). Go to original source...
    9. Fried M, et al. Bariatrická a metabolická chirurgie, MF 2011; 149-160.
    10. Mourek J, et al. Mastné kyseliny omega-3: zdraví a vývoj. 2., rozšíř. vyd. Praha: Triton, 2009.
    11. Navrátilová M, Češková E, Sobotka L. Klinická výživa v psychiatrii. Praha: Maxdorf Jesenius, 2000; 158-166, 174-178, 272.
    12. Zhao G, Etherton TD, Martin KR, et al. Anti‑inflamatory effects of polyunsaturated fatty acids in THP-1 cells. Biochem Biophys res Commun 2005; 336: 900-917. Go to original source...
    13. Barber MD, Fearon KC, Ross JA. Eicosapentaenoic acid modulates the immune response but has no effect on a mimic of antigen‑specific responses. Nutrititon. 2005; 5: 588-593. Go to original source...
    14. Rudin DO. The major psychoses and neuroses as omega-3 essential fatty acid deficiency syndrome: substrate pellagra. Biol Psychiatr 1981; 16: 837-849.
    15. Vallve JC, Uliaque K, Girona J, et al. Unsaturated fatty acids and their oxidation products stimulate CD36 gene expresion in human macrophages. Atherosclerosis. 2002; 164: 45-56.Další literatura u autorkya na www.psychiatriepropraxi.cz Go to original source... Go to PubMed...
    16. Kyle D J, Schaefer E, Patton G, et al. Low serum docosahexaenoic acid is a significant risk factor for Alzheimer's dementia. Lipids. Suppl. 1999; 34: S-243. Go to original source...
    17. Lee JY, Plakidas A, Lee WH, et al. Differential modulation of Toll‑like receptors by fatty acids: preferential inhibition by n-3 polyunsaturated fatty acids. J Lipid Res 2003; 44: 479-486. Go to original source...
    18. Salmon J A, Terano T. Effect of eicosapentaenoic acid on leukotriene B formation by human nutrophils and the relevance to inflamation. In: C. GALLI and F. FEDELI, ed. Fat production and consumption‑technologies and nutritional implications. Series A: Life Sciences, vol. 131. New York: Plenum Press 1987; 31-144. Go to original source...
    19. https://www.linkos.cz/pacient‑a-rodina/pomoc‑v-nemoci/psychologicka‑pomoc/jak‑lepe‑zvladat‑svoje‑onemocneni/jak‑zvladat‑stres‑z-nemoci‑a-lecby/vliv‑mysli‑na‑imunitni‑system‑a-nemoc-2/
    20. Pospíchal M. Vliv psychiky na nemoc a zdraví u člověka s karcinomem Kdy mysl brání rakovině růst. http://www.ncbi.nlm.nih.gov/pubmed/22287549
    21. Chida Y, Hamer M, Wardle J, Steptoe A. Do stress‑related psychosocial factors contribute to cancer incidence and survival? Nat Clin Pract Oncol. 2008; 5: 466-475. Go to original source... Go to PubMed...
    22. Glaser R, Kiecolt‑Glaser JK. Stress‑induced immune dysfunction: Implications for health. Nat Rev Immunol. 2005; 5: 243-251. Go to original source... Go to PubMed...
    23. Penninx P. National Institute og Aging 1998. http://www.jnci.oxfordjournals.org/content/90/24/1888.full Go to original source...
    24. Chida Y, Hamer M, Wardle J, Steptoe A. Do stress‑related psychosocial factors contribute to cancer incidence and survival? Nat Clin Pract Oncol 2008-9; 5: 466-475. Go to original source...
    25. Villano Bonamin L, Barbuto JA, Malucelli BE. Effects of social isolation on ehrlich tumor growth and tumor leukocyte infiltration in mice: Evidence of participation of the submaxillary salivary gland. Neuroimmunomodulation, 2001; 9: 313-318. Go to original source... Go to PubMed...
    26. Thaker PH, et al. Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma. Nat Med, 2006; 12: 939-944. Go to original source... Go to PubMed...
    27. Zhaohui Feng, Lianxin Liu, Cen Zhang, Tongsen Zheng, Jiabei Wang, Meihua Lin, Yuhan Zhao, Xiaowen Wang, Arnold J. Levine, and Wenwei Hu Chronic restraint stress attenuates p53 function and promotes tumorigenesis. Journal List Proc Natl Acad Sci U S A v.109(18); PNAS, 2012; 109(18): 7013-7018. Go to original source... Go to PubMed...
    28. Lillberg K1, Verkasalo PK, Kaprio J, Teppo L, Helenius H, Koskenvuo M. Stressful life events and risk of breast cancer in 10,808 women: a cohort study. Am J Epidemiol. 2003; 157(5): 415-423.
    29. Ayal, A et al. Marital Status and Survival in Patients With Cancer. Journal of Clinical Oncology 31. 2013; 31(1): 3869-3876. Go to original source...
    30. Allison PJ1, Guichard C, Fung K, Gilain L. Dispositional optimism predicts survival status 1 year after diagnosis in head and neck cancer patients. J Clin Oncol. 2003; 21(3): 543-548.
    31. Andersen BL(1), Farrar WB, Golden‑Kreutz D, Kutz LA, MacCallum R, Courtney ME,Glaser R. Stress and immune responses after surgical treatment for regional breast cancer.Natl J Cancer Inst. 1998 Jan 7; 90(1): 30-36. Go to original source...
    32. Vander, Arthur J. Human Physiology: The Mechanism of Body Function. 8. vyd. (s.l.): The McGraw-Hill Companies, 2001.
    33. Basu S, Nagy JA, Pal S, Vasile E, Eckelhoefer IA, Bliss VS, Manseau EJ,Dasgupta PS, Dvorak HF, Mukhopadhyay D. Nat Med. The neurotransmitter dopamine inhibits angiogenesis induced by vascular permeability factor/vascular endothelial growth factor. 2001; 7(5): 569-574. Go to original source...
    34. Humphries J, Freedom Fighters, Wales's forgotten war 2001; 1963-1993.
    35. Johnes McLean I, M, Aberfan: government and disasters. Cardiff: Welsh Academic Press, 2000. ISBN 186057033X.
    36. Austin T, Aberfan: the story of a disaster. London: Hutchinson, 1967.
    37. Navrátilová M, Hamrová M. Realimentace u závažných poruch příjmu potravy - mentální anorexie a bulimie. New EU Magazine of Medicine 2009; 1-2: 22-36.
    38. https://cs.wikipedia.org/wiki/Jasmuheen, https://jasmuheen.com/about‑jasmuheen/. Abrahams, Marc (September 12, 2012). "The Greatest Hits of Weird Science: What the Oscars could learn from the Ig Nobel Prize ceremony". Slate.com. Retrieved November 17, 2018.
    39. Waldecker M, Kautenburger T, Daumann H. Inhibition of histone‑deacetylase activity by short‑chain fatty acids and some polyphenol metabolites formed in the colon. The Journal of Nutritional Biochemistry. 2008-9; (19): 9, 587-593. Go to original source...
    40. Mazmanian S K, Round June L, Kasper DL. A microbial symbiosis factor prevents intestinal inflammatory disease. Nature. 2008-05-29, roč. 453, čís. 7195, s. 620-625. Go to original source...
    41. Rogers GB, Keating DJ, Young RL, Wong M‑L, Licinio J, Wesselingh S. From gut dysbiosis to altered brain function and mental illness: mechanisms and pathways. Mol Psychiatry 2016; 21: 738-748. Go to original source...
    42. Dinan TG, Cryan JF: Microbes, immunity, and behavior: psychoneuroimmunology meets the microbiome. Neuropsychopharmacology 2017; 42: 178-192. Go to original source... Go to PubMed...
    43. Sharon L, Hollins D, et al. Stress, microbiota, and immunity Elsevier, Behavioral Sciences 2019; 28: 66-71. Go to original source...
    44. Cryan JF, Dinan TG. Mind‑altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nat Rev Neurosci 2012; 13: 1-12 Nature Publishing Group. Go to original source...
    45. Jiang H‑Y, Zhang X, Yu Z‑H, Zhang Z, Deng M, Zhao J‑H, Ruan B. Altered gut microbiota profile in patients with generalized anxiety disorder. J Psychiatr Res 2018; 104: 130-136. Go to original source... Go to PubMed...
    46. Kelly JR, Borre Y, O' Brien C, Patterson E, Aidy El S, Deane J, Kennedy PJ, Beers S, Scott K, Moloney G et al. Transferring the blues: depression‑associated gut microbiota induces neurobehavioural changes in the rat. J Psychiatr Res 2016; 82: 109-118. Go to original source... Go to PubMed...
    47. Chen JJ, Zheng P, Liu YY, Zhong XG, Wang HY, Guo YJ, Xie P. Sex differences in gut microbiota in patients with major depressive disorder. NDT 2018; 14: 647-655. Go to original source...
    48. Schwarz E, Maukonen J, Hyytia¨ inen T, Kieseppa¨ T, Ore9sic9 M, Sabunciyan S, Mantere O, Saarela M, Yolken R, Suvisaari J. Analysis of microbiota in first episode psychosis identifies preliminary associations with symptom severity and treatment response. Schizophr Res 2018; 192: 398-403. Go to original source... Go to PubMed...
    49. Evans SJ, Bassis CM, Hein R, Assari S, Flowers SA, Kelly MB, Young VB, Ellingrod VE, McInnis MG: The gut microbiome composition associates with bipolar disorder and illness severity. J Psychiatr Res 2017; 87: 23-29. Go to original source... Go to PubMed...
    50. Luna RA, Oezguen N, Balderas M, Venkatachalam A, Runge JK, Versalovic J, Veenstra‑VanderWeele J, Anderson GM, Savidge T, Williams KC: Distinct microbiome‑neuroimmune signatures correlate with functional abdominal pain in children with autism spectrum disorder. Cell Mol Gastroenterol Hepatol 2017; 3: 218-230. Go to original source...
    51. Hsiao EY, McBride SW, Hsien S, Sharon G, Hyde ER, McCue T, Codelli JA, Chow J, Reisman SE, Petrosino JF et al. Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Cell 2013; 155: 1451-1463. 70 Psychoneuroimmunology Current Opinion in Behavioral Sciences 2019; 28: 66-71. Go to original source...
    52. de Theije CGM, Wopereis H, Ramadan M, van Eijndthoven T, Lambert J, Knol J, Garssen J, Kraneveld AD, Oozeer R: Altered gut microbiota and activity in a murine model of autism spectrum disorders. Brain Behav Immun 2014; 37: 197-206. Go to original source...
    53. Prehn‑Kristensen A, Zimmermann A, Tittmann L, Lieb W, Schreiber S, Baving L, Fischer A: Reduced microbiome alpha diversity in young patients with ADHD. PLoS One 2018; 13: e0200728-19. Go to original source... Go to PubMed...
    54. Johansson, Maria A, SjÖgren, Ylva M, Persson, Jan‑Olov. Early colonization with a group of Lactobacilli decreases the risk for allergy at five years of age despite allergic heredity. PloS One. 2011; (6)8: 23031s. Go to original source...
    55. Navrátilová M, Hamrová M. Poruchy příjmu potravy - mentální anorexie a bulimie - nejzávažnější somatické a metabolické komplikace. Způsoby realimentace. Shrnutí 30 tileté praxe z metabolického pohledu internisty. Čes‑slov Pediat 2019; 74(5): 290-300.
    56. Evans DL, Charney DS, Lewis L, Golden RN, Gorman JM, Krishnan KR, et al. Mood disorders in the medically ill: Scientific review and recommendations. Biol Psychiatry 2005; 58(3): 175-189. Go to original source...
    57. Leonard BE. Inflammation and depression: A causal or coincidental link to the pathophysiology? Acta Neuropsychiatrica 2018; 30(1): 1-16. Go to original source...
    58. Najjar S, Pearlman DM. Neuroinflammation and white matter pathology in schizophrenia: Systematic review. Schizophr Res 2015; 161(1): 102-112. Go to original source...
    59. Gialluisia A, et al. Lifestyle and biological factors influence the relationship between mental health and low‑grade inflammation, Elsevier, Brain, Behaviour, and Immunity 2020; 85: 4-13. Go to original source...
    60. Jenkins R, Ong'echa M, Othieno C, Ongeri L, Sifuna P, Omollo R, et al. Malaria, mental disorders, immunity and their inter‑relationships - A cross sectional study in a household population in a health and demographic surveillance site in Kenya. EBioMedicine 2018. https://doi.org/10.1016/j.ebiom. 2018. 11. 064 Go to original source...
    61. Jenkins R, Othieno C, Ongeri L, Ongecha M, Sifuna P, Omollo R, et al. Malaria and mental disorder: A population study in an area endemic for malaria in Kenya. World Psychiatry 2017; 16(3): 324-325. Go to original source...
    62. Young and Singh, 2018 in Gialluisia A, et al. Lifestyle and biological factors influence the relationship between mental health and low‑grade inflammation, Elsevier, Brain, Behaviour, and Immunity 2020; 85: 4-13. Go to original source...
    63. Mordmuller BG, Metzger WG, Juillard P, Brinkman BM, Verweij CL, Grau GE, et al. Tumor necrosis factor in Plasmodium falciparum malaria: High plasma level is associated with fever, but high production capacity is associated with rapid fever clearance. Eur Cytokine Netw 1997; 8(1): 29-35.
    64. Scannapieco FA. Position paper of the American Academy of Periodontology: periodontal disease as a potential risk factor for systemic disease. J Periodontol 1998; 69: 841-850.
    65. Kolenbrander PE, Anderson RN, Blehert DS, Egland PG, Foster JS, Palmer RJ. Communication among oral bacteria. Microbiol Mol Biol Rev 2002; 66: 486-505. Go to original source... Go to PubMed...
    66. Russell MW, Hajishengallis G, Childers NK, Mchalek SM. Secretory immunity in defense against cariogenic mutans streptococci. Caries Res 1999; 33: 4-15. Go to original source...
    67. Brandtzaeg P. Salivary immunoglobulins. In: Tenovuo JO, editor. Human saliva: clinical chemistry and microbiology. Boca Raton, FL: CRC Press; 1989; 1-54.
    68. Quan CP, Berneman A, Pires R, Avrameas S, Bouvet JP. Natural polyreactive secretory immunoglobulin A autoantibodies as a possible barrier to infection in humans. Infect Immun 1997; 65: 3997-4004. Go to original source... Go to PubMed...
    69. Gabay C, Kushner I. Acute‑phase proteins and other systemic responses to inflammation. N Engl J Med 1999; 340: 448-454. Go to original source...
    70. Keller PS, et al. Relations between mucosal immunity and children's mental health Elservier, Physiology & Behavior 2010; 101: 705-712. Go to original source... Go to PubMed...
    71. Tsuboi H, Hamer M, Tanaka G, Takagi K, Kinae N, Steptoe A. Responses of ultraweak chemiluminescence and secretory IgA in saliva to the induction of angry and depressive moods. Brain Behav Immun 2008; 22: 209-214. Go to original source...
    72. Izawa S, Hirata U, Kodama M, Nomura S. The effects of daily events and moods on secretory immunoglobulin A in saliva. Jpn J Physiol Psychol Psychophysiol; 25: 237-44.
    73. Stone AA, Cox DS, Valdimarsdottir H, Jandorf L, Neale JM. Evidence that secretory IgA antibody is associated with daily mood. J Pers Soc Psychol 1987; 52: 988-993. Go to original source...
    74. Takagi S, Ohira H. Effects of expression and inhibition of negative emotions on health, mood states, and salivary secretory immunoglobulin A in Japanese mildly depressed undergraduates. Percept Mot Skills 2004; 98: 1187-1198. P. S. Keller et al. / Physiology & Behavior 101 (2010) 705-712 711. Go to original source... Go to PubMed...
    75. Hewson‑Bower B, Drummond PD. Psychological treatment for recurrent symptoms of colds and flu in children. J Psychosom Res 2001; 51: 369-377. Go to original source... Go to PubMed...
    76. Gabbay V, Klein RG, Alonso CM, Babb JS, Nishawala M, De Jesus G, et al. Plasma immune dysregulation in adolescent major depressive disorder. J Affect Disord 2009; 115: 177-182. Go to original source... Go to PubMed...
    77. Pervanidou P, Kolaitis G, Charitaki S, Margeli A, Ferentinos S, Bakoula C, et al. Elevated morning serum interleukin (IL)-6 or evening salivary cortisol concentrations predict posttraumatic stress disorder in children and adolescents six months after a motor vehicle accident. Psychoneuroendocrinology 2007; 32: 991-999. Go to original source...
    78. Marsland AL, Prather AA, Peterson KL, Cohen S, Manuck SB. Antagonistic characteristics are positively associated with inflammatory markers independently of trait negative emotionality. Brain Behav Immun 2008; 22: 753-761. Go to original source...
    79. Bouman A, Heineman MJ, Faas MM. Sex hormones and the immune response in humans. Hum Reprod Update 2005; 11: 411-423. Go to original source...
    80. Dantzer R. Cytokine‑induced sickness behavior: where do we stand? Brain Behav Immun 2001; 15: 7-24. Go to original source...
    81. Dantzer R. Cytokine, sickness behavior, and depression. Immunol Allergy Clin North Am 2009; 29: 247-264. Go to original source... Go to PubMed...
    82. Mediterranean diet, stroke, cognitive impairment, and depression: a meta‑analysis. Ann. Neurol. 74, 580-591.
    83. Rabkin JG. HIV and depression: 2008 review and update. Curr HIV/AIDS Rep 2008; 5(4): 163-171. Go to original source... Go to PubMed...
    84. Krishnadas R, Cavanagh J. Depression: An inflammatory illness? J Neurol Neurosurg Psychiatry 2012; 83(5): 495-502. Go to original source...
    85. Bonaccio M, Di Castelnuovo A, Bonanni A, et al. Adherence to a Mediterranean diet is associated with a better health‑related quality of life: A possible role of high dietary antioxidant content. BMJ Open 3. 2013: https://doi.org/10.1136/bmjopen-2013- 003003. Go to original source... Go to PubMed...

    Return to the content


    Psychiatry for Practice

    Madam, Sir,
    please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
    Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

    I declare:

    1. that I have met the above instruction
    2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited

    No
    Yes

    If your statement is not true, please be aware
    that brings the risk of danger to their health or the health of others.