Psychiatr. praxi. 2021;22(2):89-93 | DOI: 10.36290/psy.2021.018

The relationship between gut microbiota and behavior

MUDr. Marcela Šoltýsová1, 2, MUDr. Aleksandra Tomova, PhD.1, prof. MUDr. Daniela Ostatníková, PhD.1
1 Fyziologický ústav, Akademické centrum výskumu autizmu, Univerzita Komenského, Lekárska fakulta, Bratislava
2 Detská psychiatrická ambulancia, Detská fakultná nemocnica s poliklinikou, Banská Bystrica

The relationship between the composition of gut microbiota and behavior is a relatively new and interesting field of research. It promises the possible use of modulation of microbiota to reduce problem behavior, as part of comprehensive approach to patients with mental disorders. This article aims to briefly describe the current state of knowledge in this area, focusing on selected pathways of communication between gut and the brain, which are associated with production of neuroactive molecules, and also describes the relationship with composition of the gut microbiota.

Keywords: gut microbiota, behavior, mental disorders.

Published: July 9, 2021  Show citation

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Šoltýsová M, Tomova A, Ostatníková D. The relationship between gut microbiota and behavior. Psychiatr. praxi. 2021;22(2):89-93. doi: 10.36290/psy.2021.018.
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    References

    1. Li J, Jia H, Cai X, et al. An integrated catalog of reference genes in the human gut microbiome. Nat Biotechnol. 2014; 32(8): 834-841. Go to original source... Go to PubMed...
    2. Forsythe P, Kunze WA. Voices from within: gut microbes and the CNS. Cell Mol Life Sci. 2013; 70(1): 55-69. Go to original source... Go to PubMed...
    3. Mueller NT, Differding MK, Østbye T, et al. Association of birth mode of delivery with infant faecal microbiota, potential pathobionts, and short chain fatty acids: a longitudinal study over the first year of life. BJOG. 2020. Go to original source...
    4. Blaser MJ, Devkota S, McCoy KD, et al. Lessons learned from the prenatal microbiome controversy. Microbiome. 2021; 9(1): 8. Go to original source... Go to PubMed...
    5. Wang S, Egan M, Ryan CA, et al. A good start in life is important-perinatal factors dictate early microbiota development and longer term maturation. FEMS Microbiol Rev. 2020; 44(6): 763-781. Go to original source... Go to PubMed...
    6. Blaser MJ. Antibiotic use and its consequences for the normal microbiome. Science. 2016; 352(6285): 544-545. Go to original source... Go to PubMed...
    7. De Filippo C, Cavalieri D, Di Paola M, et al. Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa. Proc Natl Acad Sci U S A. 2010; 107(33): 14691-14696. Go to original source... Go to PubMed...
    8. Yatsunenko T, Rey FE, Manary MJ, et al. Human gut microbiome viewed across age and geography. Nature. 2012; 486(7402): 222-227. Go to original source... Go to PubMed...
    9. Sampson TR, Mazmanian SK. Control of brain development, function, and behavior by the microbiome. Cell Host Microbe. 2015; 17(5): 565-576. Go to original source... Go to PubMed...
    10. Jurek L, Sevil M, Jay A, et al. Is there a dysbiosis in individuals with a neurodevelopmental disorder compared to controls over the course of development? A systematic review. Eur Child Adolesc Psychiatry. 2020. Go to original source... Go to PubMed...
    11. Neufeld KA, Kang N, Bienenstock J, Foster JA. Effects of intestinal microbiota on anxiety-like behavior. Commun Integr Biol. 2011; 4(4): 492-494. Go to original source...
    12. Borre YE, O'Keeffe GW, Clarke G, et al. Microbiota and neurodevelopmental windows: implications for brain disorders. Trends Mol Med. 2014; 20(9): 509-518. Go to original source... Go to PubMed...
    13. Silva YP, Bernardi A, Frozza RL. The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication. Front Endocrinol (Lausanne). 2020; 11: 25. Go to original source... Go to PubMed...
    14. Cussotto S, Sandhu KV, Dinan TG, Cryan JF. The Neuroendocrinology of the Microbiota-Gut-Brain Axis: A Behavioural Perspective. Front Neuroendocrinol. 2018; 51: 80-101. Go to original source... Go to PubMed...
    15. Boonchooduang N, Louthrenoo O, Chattipakorn N, Chattipakorn SC. Possible links between gut-microbiota and attention-deficit/hyperactivity disorders in children and adolescents. Eur J Nutr. 2020; 59(8): 3391-403. Go to original source... Go to PubMed...
    16. Strandwitz P. Neurotransmitter modulation by the gut microbiota. Brain Res. 2018; 1693(Pt B): 128-133. Go to original source... Go to PubMed...
    17. Sharon G, Cruz NJ, Kang DW, Gandal MJ, Wang B, Kim YM, et al. Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice. Cell. 2019; 177(6): 1600-18.e17. Go to original source... Go to PubMed...
    18. Iglesias-Vázquez L, Van Ginkel Riba G, Arija V, Canals J. Composition of Gut Microbiota in Children with Autism Spectrum Disorder: A Systematic Review and Meta-Analysis. Nutrients. 2020; 12(3). Go to original source... Go to PubMed...
    19. Sandler RH, Finegold SM, Bolte ER, et al. Short-term benefit from oral vancomycin treatment of regressive-onset autism. J Child Neurol. 2000; 15(7): 429-435. Go to original source... Go to PubMed...
    20. Roussin L, Prince N, Perez-Pardo P, et al. Role of the Gut Microbiota in the Pathophysiology of Autism Spectrum Disorder: Clinical and Preclinical Evidence. Microorganisms. 2020; 8(9). Go to original source... Go to PubMed...
    21. Ohland CL, Kish L, Bell H, et al. Effects of Lactobacillus helveticus on murine behavior are dependent on diet and genotype and correlate with alterations in the gut microbiome. Psychoneuroendocrinology. 2013; 38(9): 1738-1747. Go to original source... Go to PubMed...
    22. Abdellatif B, McVeigh C, Bendriss G, Chaari A. The Promising Role of Probiotics in Managing the Altered Gut in Autism Spectrum Disorders. Int J Mol Sci. 2020; 21(11). Go to original source... Go to PubMed...
    23. Shaaban SY, El Gendy YG, Mehanna NS, et al. The role of probiotics in children with autism spectrum disorder: A prospective, open-label study. Nutr Neurosci. 2018; 21(9): 676-681. Go to original source... Go to PubMed...
    24. Kang DW, Adams JB, Coleman DM, et al. Long-term benefit of Microbiota Transfer Therapy on autism symptoms and gut microbiota. Sci Rep. 2019; 9(1): 5821. Go to original source... Go to PubMed...
    25. Sukmajaya AC, Lusida MI, Soetjipto, Setiawati Y. Systematic review of gut microbiota and attention-deficit hyperactivity disorder (ADHD). Ann Gen Psychiatry. 2021; 20(1): 12. Go to original source... Go to PubMed...
    26. Hiergeist A, Gessner J, Gessner A. Current Limitations for the Assessment of the Role of the Gut Microbiome for Attention Deficit Hyperactivity Disorder (ADHD). Front Psychiatry. 2020; 11: 623. Go to original source... Go to PubMed...
    27. Arentsen T, Raith H, Qian Y, et al. Host microbiota modulates development of social preference in mice. Microb Ecol Health Dis. 2015; 26: 29719. Go to original source... Go to PubMed...
    28. Kumperscak HG, Gricar A, Ülen I, Micetic-Turk D. A Pilot Randomized Control Trial With the Probiotic Strain. Front Psychiatry. 2020; 11: 181. Go to original source... Go to PubMed...
    29. Evrensel A, Tarhan KN. Emerging role of Gut-microbiota-brain axis in depression and therapeutic implication. Prog Neuropsychopharmacol Biol Psychiatry. 2021; 106: 110138. Go to original source... Go to PubMed...
    30. Morais LH, Schreiber HL, Mazmanian SK. The gut microbiota-brain axis in behaviour and brain disorders. Nat Rev Microbiol. 2021; 19(4): 241-255. Go to original source... Go to PubMed...
    31. Bruch JD. Intestinal infection associated with future onset of an anxiety disorder: Results of a nationally representative study. Brain Behav Immun. 2016; 57: 222-226. Go to original source... Go to PubMed...
    32. Desbonnet L, Garrett L, Clarke G, et al. Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression. Neuroscience. 2010; 170(4): 1179-1188. Go to original source... Go to PubMed...
    33. Bravo JA, Forsythe P, Chew MV, et al. Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proc Natl Acad Sci U S A. 2011; 108(38): 16050-16055. Go to original source... Go to PubMed...
    34. Watson H, Mitra S, Croden FC, et al. A randomised trial of the effect of omega-3 polyunsaturated fatty acid supplements on the human intestinal microbiota. Gut. 2018; 67(11): 1974-1983. Go to original source... Go to PubMed...
    35. Tomova A, Bukovsky I, Rembert E, et al. The Effects of Vegetarian and Vegan Diets on Gut Microbiota. Front Nutr. 2019; 6: 47. Go to original source... Go to PubMed...
    36. Tomova A, Soltys K, Kemenyova P, et al. The Influence of Food Intake Specificity in Children with Autism on Gut Microbiota. Int J Mol Sci. 2020; 21(8). Go to original source... Go to PubMed...
    37. Garcia SC, Mikhail ME, Keel PK, et al. Increased rates of eating disorders and their symptoms in women with major depressive disorder and anxiety disorders. Int J Eat Disord. 2020; 53(11): 1844-1854. Go to original source... Go to PubMed...

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