Psychiatr. pro Praxi, 2005; 5: 226-228

MULTIPLE SCLEROSIS AND DEPRESSION

Eva Havrdová1, MUDr. Zdena Čechová2
1 Centrum pro demyelinizační onemocnění Neurologická klinika 1. LF UK a VFN Praha
2 NZZ Psychiatrická ambulance, Rakovník

Multiple sclerosis (MS) is a multifocal autoimmune disorder of CNS, characterized besides neurological signs also by both cognitive and affective dysfunction. In old text-books, MS is joined with euphoria which is nearly no more seen in clinical practice. On the contrary, at least 50% of MS patients experience depression during the course of their disease. Depression is very often underdiagnosed and undertreated. Part of the pathophysiology of depression in MS is the inflammation itself. Despite of this, depression in MS patients is very well treatable with modern antidepressants. The treatment of depression substantially improves the quality of life of MS patients.

Keywords: Key words: multiple sclerosis, depression, SSRI, immunopathogenesis, amitriptylin.

Published: February 1, 2006  Show citation

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Havrdová E, Čechová Z. MULTIPLE SCLEROSIS AND DEPRESSION. Psychiatr. praxi. 2005;9(5):226-228.
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    References

    1. Alfonso J, Pollevick GD, Van Der Hart MG, Flugge G, Fuchs E, Frasch AC. Identification of genes regulated by chronic psychosocial stress and antidepressant treatment in the hippocampus. Eur J Neurosci. 2004 Feb; 19(3): 659-666. Go to original source... Go to PubMed...
    2. Benedict RH, Fischer JS, Archibald CJ, Arnett PA, Beatty WW, Bobholz J, Chelune GJ, Fisk JD, Langdon DW, Caruso L, Foley F, LaRocca NG, Vowels L, Weinstein A, DeLuca J, Rao SM, Munschauer F. Minimal neuropsychological assessment of MS patients: a consensus approach. Clin Neuropsychol. 2002 Aug; 16(3): 381-397. Go to original source... Go to PubMed...
    3. Feinstein A, Roy P, Lobaugh N, Feinstein K, O'Connor P, Black S. Structural brain abnormalities in multiple sclerosis patients with major depression. Neurology. 2004 Feb 24; 62(4): 586-590. Go to original source... Go to PubMed...
    4. Fisk JD, Morehouse SA, Brown Mg, et al. Hospital-based psychiatric service utilization and morbidity in multiple sclerosis. Can J Neurol Sci 1998; 25: 230-235. Go to original source... Go to PubMed...
    5. Hashimoto K, Shimizu E, Iyo M. Critical role of brain-derived neurotrophic factor in mood disorders. Brain Res Brain Res Rev. 2004 May; 45(2): 104-114. Go to original source... Go to PubMed...
    6. Havrdová E, Horáková D. Roztroušená skleróza. Postgraduální medicína 2004 (6) 4: 382-389.
    7. Hornstein A, Seliger TG, Flax J, et al. Fluoxetine in treating emotional lability. Brain Inj 1993; 7/2: 189. Go to original source... Go to PubMed...
    8. Kovářů H, Fišerová A, Kovářů F. Neuroimunomodulační změny vyvolané psychotropními látkami. In: Sikora J, Fišar Z. Neurobiologie duševních poruch, Galén 1999: 96-99.
    9. Kovářů H, Fišerová A, Lisá V, et al. Fluoxetine induced changes in C-6 glioma cells and NK Lymphocytes. In: Sikora J, Fišar Z, Petrovický P, Jirák R. Biologické podklady psychických poruch, Galén 1997: 108-111.
    10. Noy S, Achiron A, Gabbay U. A new approach to affective symptoms in relapsing-remitting multiple sclerosis. Compr Psychiatry 1995; 36: 390-395. Go to original source... Go to PubMed...
    11. Patten SB, Metz LM. Depression in multiple sclerosis. Psychother Psychosom 1997; 66: 286-292. Go to original source... Go to PubMed...
    12. Piťha J, Havrdová E: Axonální patologie u roztroušené sklerózy. Čes a Slov Neurol a Neuroch 68/101, 2005; No 3, 154-158.
    13. Scott TF, Allen D, Price TR, McConnell H, Lang D. Characterization of major depression symptoms in multiple sclerosis patients. J Neuropsychiatry Clin Neurosci. 1996 Summer; 8(3): 318-323. Go to original source... Go to PubMed...
    14. Smith RS. The macrophage theory of depression. Med Hypotheses. 1991 Aug; 35(4): 298-306. Go to original source... Go to PubMed...
    15. Stenager EN, Koch-Henriksen N, Stenager E. Risk factors for suicide in multiple sclerosis. Psychother Psychosom 1996; 65: 86-90. Go to original source... Go to PubMed...
    16. Sullivan MJ, Weinshenker B, Mikail S, Edgley K. Depression before and after diagnosis of multiple sclerosis. Mult Scler 1995; 1: 104-108. Go to original source... Go to PubMed...
    17. Zivadinov R, Rudick RA, De Masi R, Nasuelli D, Ukmar M, et al. Effects of IV methylprednisolone on brain atrophy in relapsing-remitting MS. Neurology. 2001; 57(7): 1239-1247. Go to original source... Go to PubMed...

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