Psychiatr. praxi 2017; 18(2): 60-63 | DOI: 10.36290/psy.2017.011

Treatment of depressive disorder with cognitive dysfunction

prof. MUDr. Eva Češková, CSc.

1CEITEC-MU, Brno

2Psychiatrická klinika FN Brno

3KNP LF Ostravské univerzity, Ostrava

4Oddělení psychiatrie, FN Ostrava

Cognitive dysfunction frequently occurs in acute depression and can persist into remission. Cognitive impairments impacts on

patient functioning and negatively influence ability to perform adequately at work. As evidenced by the results of numerous

studies drugs with anticholinergic effect (e. g. tricyclic antidepressants) may adversly affect cognitive functions. The most frequently

prescribed antidepressants, selective serotonin reuptake inhibitors may improve cognitivy dysfunction in depression.

Agent also including a noradrenergic component such as selective serotonin and noradrenaline reuptak inhibitorts appears to

be more effective in respect to cognitive functions compared to SSRI treatment. Based on the available data, the new multimodal

antidepressant vortioxetine may have a specific pro-cognitive effects.

Keywords: cognitive dysfunction, depressive disorder, antidepressants, negative bias

Published: July 1, 2017  Show citation