Psychiatr. praxi. 2021;22(3):e15-e25 [Neurol. praxi. 2021;22(3):194-200]

New insights on the treatment of dementia

Mgr. Radoslava Bajtoąová1, doc. MUDr. Iva Holmerová, Ph.D.2, 3, doc. MUDr. Robert Rusina, Ph.D.1
1 Neurologická klinika, 3. LF UK a FTN, Praha
2 Centrum pro studium dlouhověkosti a dlouhodobé péče, FHS UK, Praha
3 Gerontologické centrum, Praha

Therapeutic aspects in dementia are focused on complex approaches and are based on four interlinked columns: psychosocial interventions (nonpharmacological interventions and caregiver support), pharmacotherapy (mainly acetylcholinesterase inhibitors and memantine), neuropsychiatry (management of behavioral and psychologic symptoms of dementia) and palliative care (early palliative interventions; complex palliative approach in advanced stages of dementia). Different therapeutic modalities are described in detail and particular impact is attributed to interdisciplinarity and close cooperation with relatives, since the diagnosis is established.

Keywords: dementia, Alzheimer's disease, acetylcholinesterase inhibitors and memantine, psychosocial interventions, behavioral manifestations in dementia.

Published: October 14, 2021  Show citation

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Bajtoąová R, Holmerová I, Rusina R. New insights on the treatment of dementia. Psychiatr. praxi. 2021;22(3):e15-25.
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    References

    1. Abraha I, Rimland JM, Trotta FM, Dell'Aquila G, Cruz-Jentoft A, Petrovic M, Gudmundsson A, Soiza R, O'Mahony D, Guaita A, Cherubini A. Systematic review of systematic reviews of non-pharmacological interventions to treat behavioural disturbances in older patients with dementia. The SENATOR-OnTop series. BMJ Open 2017; 7: e012759. Go to original source... Go to PubMed...
    2. Alzheimer's Association. Alzheimer's Disease Facts and Figures. Alzheimers Dement 2018; 14: 367-429. Go to original source...
    3. Bayer AJ, Bullock R, Jones RW, Wilkinson D, Paterson KR, Jenkins L, Millais SB, Donoghue S. Evaluation of the safety and immunogenicity of synthetic Abeta42 (AN1792) in patients with AD. Neurology 2005; 64: 94-101. Go to original source... Go to PubMed...
    4. Boxer AL, Knopman DS, Kaufer DI, Grossman M, Onyike C, Graf-Radford N, Mendez M, Kerwin D, Lerner A, Wu CK, Koestler M, Shapira J, Sullivan K, Klepac K, Lipowski K, Ullah J, Fields S, Kramer JH, Merrilees J, Neuhaus J, Mesulam MM, Miller BL. Memantine in patients with frontotemporal lobar degeneration: a multicentre, randomised, doubleblind, placebo-controlled trial. Lancet Neurol 2013; 12: 149-156. Go to original source... Go to PubMed...
    5. Brodaty H, Donkin M. Family caregivers of people with dementia. Dialogues Clin Neurosci 2009; 11: 217-228. Go to original source... Go to PubMed...
    6. Camic PM, Baker EL, Tischler V. Theorizing how art gallery interventions impact people with dementia and their caregivers. Gerontologist 2016; 56: 1033-1041. Go to original source... Go to PubMed...
    7. Cammisuli DM, Danti S, Bosinelli F, Cipriani G. Non-pharmacological interventions for people with Alzheimer's disease: A critical review of the scientific literature from the last ten years. Eur Ger Med 2016; 7: 57-64. Go to original source...
    8. Deshmukh SR, Holmes J, Cardno A. Art therapy for people with dementia. Cochrane Database Syst Rev 2018; 9: CD011073. Go to original source... Go to PubMed...
    9. Duan Y, Lu L, Chen J, Wu C, Liang J, Zheng Y, Wu J, Rong P, Tang C. Psychosocial interventions for Alzheimer's disease cognitive symptoms: a Bayesian network meta-analysis. BMC Geriatr 2018; 18: 175. Go to original source... Go to PubMed...
    10. Fuchs A, Martyr A, Goh AM, Sabates J, Clare L. Cognitive training for people with mild to moderate dementia. Cochrane Database Syst Rev 2019; 3: CD013069.
    11. Holmerova I, Balackova N, Baumanova M, Hajkova L, Hradcova D, Hyblova P, Wija P. Strategie České alzheimerovské společnosti P-PA-IA. Geriatrie a Gerontologie 2013; 2: 158-164.
    12. Hort J. Nová guidelines pro diagnostiku a léčbu Alzheimerovy choroby. Neurol. praxi 2011; 12: 277-281.
    13. Hradcová D. Dining in long-term care for persons with dementia. Vienna: Symposium and proceedings of the 22nd Alzheimer Europe Congres 2012.
    14. Hroudová J. Výzkum nových léčiv u Alzheimerovy choroby. Psychiatr. praxi 2017; 18: 7-10. Go to original source...
    15. Chatterton WB, Baker F Morgan K. The singer or the singing: who sings individually to persons with dementia and what are the effects? Am J Alzheimers Dis Other Demen 2010; 25: 641-649. Go to original source... Go to PubMed...
    16. Lebert F, Stekke W, Hasenbroekx C, Pasquier F. Frontotemporal dementia: a randomised, controlled trial with trazodone. Dement Geriatr Cogn Disord 2004; 17: 355-359. Go to original source... Go to PubMed...
    17. Livingston G, Sommerlad A, Orgeta V, Costafreda SG, Huntley J, Ames D, Mukadam N. Dementia prevention, intervention, and care. Lancet 2017; 390: 2673-2734. Go to original source... Go to PubMed...
    18. Livingston G, Huntley J, Sommerlad A, Ames D, Ballard C, Banerjee S, Mukadam N. Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. Lancet 2020; 396: 413-446. Go to original source... Go to PubMed...
    19. Logsdon RG, McCurry SM, Teri L. Evidence-Based Interventions to Improve Quality of Life for Individuals with Dementia. Alzh care today 2007; 8: 309-318.
    20. Mahendran R, Gandhi M, Moorakonda RB, Wong J, Kanchi MM, Fam J, Rawtaer I, Kumar AP, Feng L, Kua EH. Art therapy is associated with sustained improvement in cognitive function in the elderly with mild neurocognitive disorder: findings from a pilot randomized controlled trial for art therapy and music reminiscence activity versus usual care. Trials 2018; 19: 615. Go to original source... Go to PubMed...
    21. Matthews S. Dementia and the Power of Music Therapy. Bioethics 2015; 29: 573-579. Go to original source... Go to PubMed...
    22. Mayeux R, Sano M. Treatment of Alzheimer's disease. N Engl J Med 1999; 341: 1670-1779. Go to original source... Go to PubMed...
    23. McDermott O, Charlesworth G, Hogervorst E, Stoner C, Moniz-Cook E, Spector A, Orrell M. Psychosocial interventions for people with dementia: a synthesis of systematic reviews. Aging Ment Health 2019; 23: 393-403. Go to original source... Go to PubMed...
    24. Mendez MF, Shapira JS, McMurtray A, Licht E. Preliminary findings: behavioral worsening on donepezil in patients with frontotemporal dementia. Am J Geriatr Psychiatry 2007; 5: 84-87. Go to original source... Go to PubMed...
    25. Rusina R, Rusinová K, Holmerová I, ©imek J. Léčba pokročilé demence - paliativní přístup. Neurol. praxi 2010; 11: 16-19.
    26. Rusina R, ©peciánová ©. Paliativní aspekty u pokročilé demence. Neurol. praxi 2020; 21: 100-102. Go to original source...
    27. Rusina R, Matěj R, Cséfalvay Zs, Keller J, Franková V, Vyhnálek M. Frontotemporální demence. Cesk Slov Neurol N 2021; 84(117): 9-29. Go to original source...
    28. Scales K, Zimmerman S, Miller SJ. Evidence-Based Nonpharmacological Practices to Address Behavioral and Psychological Symptoms of Dementia. Gerontologist 2018; 58(Suppl 1): S88-S102. Go to original source... Go to PubMed...
    29. Schneider L. A resurrection of aducanumab for Alzheimer's disease. Lancet Neurol 2020; 19: 111-112. Go to original source... Go to PubMed...
    30. Small JA, Gutman G. Recommended and reported use of communication strategies in alzheimer caregiving. Alzheimer Dis Assoc Disord 2002; 16: 270-278. Go to original source... Go to PubMed...
    31. Storey R. Pokroky ve vývoji nových léčiv pro Alzheimerovu chorobu a méně časté demence. In Rusina R, Matěj R. et al. Neurodegenerativní onemocnění, 2. přepracované a doplněné vydání, Mladá fronta Praha, 2019; 367-373.
    32. Testad I, Corbett A, Aarsland D, Lexow KO, Fossey J, Woods B, Ballard C. The value of personalized psychosocial interventions to address behavioral and psychological symptoms in people with dementia living in care home settings: a systematic review. Int Psychogeriatr 2014; 26: 1083-1098. Go to original source...
    33. Tolar M, Abushakra S, Hey JA, Porsteinsson A, Sabbagh M. Aducanumab, gantenerumab, BAN2401, and ALZ-801 - the first wave of amyloid-targeting drugs for Alzheimer's disease with potential for near term approval. Alzheimers Res Ther 2020; 12: 95. Go to original source... Go to PubMed...
    34. Uhrová T, Roth J. a kol. Neuropsychiatrie. Maxdorf Praha, 2020: 976.
    35. Valią M, Masopust J, Pavelek Z. Farmakoterapie nealzheimerovských typů demencí. Neurol. praxi 2020; 21: 41-45. Go to original source...
    36. van Dyck CH, Arnsten AFT, Padala PR, Brawman-Mintzer O, Lerner AJ, Porsteinsson AsP, Scherer RW, Levey AI, Herrmann N, Jamil N, Mintzer JE, Lanctôt KL, Rosenberg PB. Neurobiologic Rationale for Treatment of Apathy in Alzheimer's Disease with Methylphenidate. Am J Geriatr Psychiatry. Am J Geriatr Psychiatry 2021; 29: 51-62. Go to original source... Go to PubMed...
    37. Volicer L. End-of-life Care for People with Dementia in Assisted Living and Nursing Homes. Tampa: Alzheimer's Association; 2005.

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