Psychiatr. praxi. 2022;23(2):121-123 | DOI: 10.36290/psy.2022.026
Case study: antidepressants and triptans - is it possible to use them in combination?
- Psychiatrická nemocnice Bohnice, Praha; Ústav aplikované farmacie, Farmaceutická fakulta, Masarykova univerzita, Brno
The case report deals with the selection of suitable psychotropic drugs from the group of antidepressants in a patient with anxiety disorder and at the same time suffering from frequent migraine attacks. The interactions of serotonergic antidepressants and triptans (antimigraine drugs) has been widely described in the literature. We deal with concerns from the development of serotonin syndrome, which can be a life-threatening side effect. In practice, there is a need to assess the clinical severity of each drug interaction so that we do not overestimate or underestimate its importance. By incorrect interpretation of the drug interaction, patient can be endangered with side effects or ineffectiveness of therapy. This case study aims to demonstrate the second case described, where the patient was initially undertreated for fear of interaction, which significantly reduced his quality of life.
Keywords: drug interactions, antidepressants, triptans, serotonine syndrome.
Published: June 16, 2022 Show citation
References
- Ereshefsky L, Stanford J, Grothe D. Antidepressant Drug‑Drug Interaction Profile Update. Drugs R D. 2005;6(6):323-336.
Go to original source... 
Go to PubMed... - Lincová D et Farghali H. Základní a aplikovaná farmakologie. 2. vydání. Praha: Galén. 2007. ISBN 978-80-7262-373-0.
- Lüllmann H, Mohr K, Wehling M. Farmakologie a toxikologie. Praha: Grada. 2004. ISBN 80-247-0836-1.
- Boyer EW. Serotonine syndrome (serotonine toxicity). UpToDate. 2021. Available from: www.uptodate.com
- Tašková I et al. Psychofarmaka v kazuistikách. 1. vydání. Praha: Maxdorf Jessenius. 2021. ISBN 978-80-7245-678-8.
- Vojtíšek P, Nalos D. Serotoninový syndrom - kazuistika. Anest. intenziv. Med. 2011;22(3):161-2.
- Prokeš M, Suchopár J. Serotoninový syndrom: co bychom o něm měli vědět. Medicína pro praxi. 2014;11(5):226-230.
- Farmakoterapeutické informace. Serotoninový syndrom. 1/2015. Dostupné na: www.sukl.cz
- Mohr P. Serotoninový syndrom - diagnostika, terapie, prevence, Psychiatr. praxi. 2001;3:117-120.
- Bouček J, Pidrman V. Psychofarmaka v medicíně. Praha: Grada. 2005. ISBN 80-247-1136-2.
- Ritsner SM. Polypharmacy in Psychiatry Practice Volume I. New York: Springer. 2013. Go to original source...
- Schwedt TJ, Garza I. Preventive treatment in episodic migraine in adults. UpToDate. 2021. Available from: www.uptodate.com
- Orlova Y, et al. Association of Coprescription of Triptan Antimigraine Drugs and Selective Serotonin Reuptake Inhibitor or Selective Norepinephrine Reuptake Inhibitor Antidepressants With Serotonin Syndrome. JAMA Neurol. 2018;75(5):566-572. Go to original source... Go to PubMed...